DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation.

DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation.
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DOI:
10.1111/tid.12177
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发表时间:
2014-02
期刊:
Transplant infectious disease : an official journal of the Transplantation Society
影响因子:
--
通讯作者:
Tan CS
Tan CS
中科院分区:
其他
文献类型:
--
作者:
Chalkias S;Mackenzie MR;Gay C;Dooley C;Marty FM;Moss RB;Li T;Routh RL;Walsh SR;Tan CS

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副流感病毒感染是异基因造血干细胞移植(HSCT)患者发病率和死亡率较高的原因。DAS 181是一种新型抗病毒药物,具有抗流感和副流感病毒活性。据我们所知,我们报告了在患有重度副流感病毒肺病的通气HSCT患者中成功使用DAS 181的前2例病例。
Parainfluenza infection is a cause of significant morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) patients. DAS181 is a novel antiviral agent with activity against influenza and parainfluenza. We report the first 2 cases, to our knowledge, of successful DAS181 use in ventilated HSCT patients with severe parainfluenza lung disease.
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