Extracellular matrix contribution to skin wound re-epithelialization
Extracellular matrix contribution to skin wound re-epithelialization
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DOI：
10.1016/j.matbio.2018.01.002
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发表时间：
2019-01-01
期刊：
影响因子：
6.9
通讯作者：
Garnier, Cecile
中科院分区：
文献类型：
--
作者：
Rousselle, Patricia;Montmasson, Marine;Garnier, Cecile
皮肤作为屏障的能力主要由维持皮肤连续性和完整性并在受伤后恢复的细胞决定。成年哺乳动物皮肤伤口的愈合是一个复杂的多步骤过程，涉及血液凝块形成、炎症、再上皮化、肉芽组织形成、新生血管和重塑等多个阶段。在有利的条件下，表皮再生在损伤后几个小时内开始，并需要几天的时间，直到由于基底膜的重组而使上皮表面完整。再生依赖于许多信号信号和发生在表皮和其他参与组织中的多种细胞过程。多种调节因子参与其中，包括生长因子、细胞因子、基质金属蛋白酶、细胞受体和细胞外基质成分。在这里，我们重点讨论在伤口愈合过程中影响表皮再生的细胞外基质蛋白的参与。(C)2018爱思唯尔B.V.保留所有权利。
The ability of skin to act as a barrier is primarily determined by cells that maintain the continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult mammals is a complex multi-step process that involves overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation tissue formation, neovascularization, and remodeling. Under favorable conditions, epidermal regeneration begins within hours after injury and takes several days until the epithelial surface is intact due to reorganization of the basement membrane. Regeneration relies on numerous signaling cues and on multiple cellular processes that take place both within the epidermis and in other participating tissues. A variety of modulators are involved, including growth factors, cytokines, matrix metalloproteinases, cellular receptors, and extracellular matrix components. Here we focus on the involvement of the extracellular matrix proteins that impact epidermal regeneration during wound healing. (C) 2018 Elsevier B.V. All rights reserved.