β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation
β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation
复制标题
β-羟基丁酸可能通过增加组蛋白 3-赖氨酸 9-β-羟基丁酰化来减轻小鼠的抑郁行为。
DOI：
10.1016/j.bbrc.2017.05.184
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发表时间：
2017-08-19
影响因子：
3.1
通讯作者：
Xu, Xingshun
中科院分区：
文献类型：
--
作者：
Chen, Li;Miao, Zhigang;Xu, Xingshun
表观遗传学调控被认为是环境应激刺激和潜在基因网络功能改变之间的机制界面。应激后体内代谢物的变化有助于组蛋白的修饰。组蛋白3-赖氨酸9-β-羟基丁酸化（H3 k9 bhb）是一种新的由β-羟基丁酸诱导的组蛋白修饰标志物，可能参与抑郁症的发生发展。为了研究H3 k9 bhb在抑郁症中的作用，对小鼠和细胞进行了实验。H3 k9 bhb在抑郁小鼠脑中减少。外源性β-羟基丁酸改善抑郁行为，逆转H3 K9 bhb和BDNF的减少。我们发现H3 k9 bhb在抑郁症中发挥作用，并首次通过H3 k9 bhb将BHB和BDNF联系起来。我们的研究结果强调了代谢调节在抑郁症表观遗传学中的关键作用。(C)2017爱思唯尔公司All rights reserved.
Epigenetics regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network. Metabolite changes in vivo after stress contribute to histone modification. Histone3-lysine9-beta-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by beta-hydroxybutyrate, may participate in the development of depression. To examine the role of H3k9bhb in depression, experiments were performed on mice and cells. H3k9bhb were reduced in the brain of depressive mice. Exogenous beta-hydroxybutyrate ameliorated depressive behaviors and reversed the reduction of H3K9bhb and BDNF. We showed that H3k9bhb played a role in depression, and firstly linked BHB and BDNF via H3k9bhb. Our findings emphasized the crucial role of metabolic regulation on epigenetics in depression. (C) 2017 Elsevier Inc. All rights reserved.