Molecular cues for development and regeneration of salivary glands.
Molecular cues for development and regeneration of salivary glands.
复制标题
DOI：
10.14670/hh-29.305
复制
发表时间：
2014-03
影响因子：
2
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Liu F;Wang S
由舍格伦综合征或头颈癌放疗引起的唾液腺功能减退严重影响了数百万患者的生活质量。目前没有治愈性治疗是可用于不可逆的少涎，而再生策略，针对唾液干/祖细胞是有前途的。然而，这些策略的成功受到唾液腺再生的分子线索缺乏见解的限制。唾液腺形态发生的分子调控的最新进展为识别潜在的再生线索提供了有价值的线索。在涎腺的器官发生过程中，上皮细胞、间充质细胞、内皮细胞、细胞外基质和支配神经之间存在着复杂的信号分子网络。在这里，我们讨论了几个相互作用的细胞间信号通路的作用，即，FGF、Wnt、Hedgehog、Eda、Notch、Chrm 1/HB-EGF和Laminin/Integrin途径在唾液腺发育中的作用及其促进唾液腺再生的潜力。
The hypofunction of salivary glands caused by Sjögren’s Syndrome or radiotherapy for head and neck cancer significantly compromises the quality of life of millions patients. Currently no curative treatment is available for the irreversible hyposalivation, whereas regenerative strategies targeting salivary stem/progenitor cells are promising. However, the success of these strategies is constrained by the lack of insights on the molecular cues of salivary gland regeneration. Recent advances in the molecular controls of salivary gland morphogenesis provided valuable clues for identifying potential regenerative cues. A complicated network of signaling molecules between epithelia, mesenchyme, endothelia, extracellular matrix and innervating nerves orchestrate the salivary gland organogenesis. Here we discuss the roles of several cross-talking intercellular signaling pathways, i.e., FGF, Wnt, Hedgehog, Eda, Notch, Chrm1/HB-EGF and Laminin/Integrin pathways, in the development of salivary glands and their potentials to promote salivary regeneration.