Frontal metabolic activity contributes to individual differences in vulnerability toward total sleep deprivation-induced changes in cognitive function
Frontal metabolic activity contributes to individual differences in vulnerability toward total sleep deprivation-induced changes in cognitive function
复制标题
额叶代谢活动导致个体差异，易受完全睡眠剥夺引起的认知功能变化的影响。
DOI：
10.1111/jsr.12354
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发表时间：
2016-04-01
影响因子：
4.4
通讯作者：
Tian，Jie
中科院分区：
文献类型：
--
作者：
Xu，Junling;Zhu，Yuanqiang;Tian，Jie
完全睡眠剥夺对认知功能的影响具有显著的个体差异。尽管已经取得了一些进展，但个体差异对完全睡眠剥夺的反应机制尚未明确阐明。静息状态下的脑代谢是支持大脑日常功能的关键生理过程之一，可能在这些个体差异中发挥重要作用。22名20至26岁的右撇子参与者（9名女性和13名男性）在休息清醒状态和24小时的完全睡眠剥夺后完成了一项数学处理任务。氟- 18氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描用于研究脑代谢变化。数学任务是在正电子发射断层扫描完成后进行的。采用相关分析探讨认知表现变化与脑代谢变化之间的相关性。在吞吐量变化中发现了很大的个体间差异，但这些个体间差异与基线或剥夺后的表现水平无关。具体而言，数学处理任务吞吐量的下降与额上内侧回的代谢变化显著相关。这些发现表明，额叶代谢活动在清醒诱导的认知能力障碍中有个体差异。
Substantial individual differences characterize the changes induced by total sleep deprivation on cognitive functions. Despite some progress having been achieved, the mechanisms of individual differences in response to total sleep deprivation have not been clearly elucidated. Cerebral metabolism in the resting state is among the key physiological processes supporting the daily function of the brain, and may play an important role in these individual differences. Twenty‐two right‐handed participants (nine females and 13 males) between 20 and 26 years old completed a mathematical processing task both in resting wakefulness and after 24 h of total sleep deprivation. Fluorine‐18 fluorodeoxyglucose positron emission tomography‐computed tomography was used to investigate brain metabolism changes. The mathematical task was performed after the positron emission tomography scans were completed. Correlation analysis was used to investigate the correlations between cognitive performance changes and brain metabolism changes. Large inter‐individual differences were found in the throughput changes, but these inter‐individual differences were not associated with baseline or post‐deprivation performance levels. Specifically, deterioration of throughput on the mathematical processing task was significantly correlated with metabolism changes in the superior frontal medial gyrus. These findings suggested that frontal metabolic activity contributes to individual differences in waking‐induced impairment of cognitive performance.