Functional MR imaging of a simulated balance task
Functional MR imaging of a simulated balance task
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DOI：
10.1016/j.brainres.2014.01.033
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发表时间：
2014-03-25
期刊：
影响因子：
2.9
通讯作者：
Loughlin, Patrick J.
中科院分区：
文献类型：
--
作者：
Karim, Helmet T.;Sparto, Patrick J.;Loughlin, Patrick J.
人类的姿势控制依赖于前庭、视觉和本体感觉输入的信息，随着年龄的增长而退化，跌倒是老年人受伤的主要原因。在过去的十年里，为了更好地了解脊柱上对平衡和行走的控制，人们进行了功能神经成像研究。众所周知，主动平衡涉及大脑中的皮质和皮质下结构，但在这些任务中对大脑的神经成像一直受到限制。关于衰老对姿势和步态功能神经成像的影响的研究直到最近才开始。在这项研究中，开发了一种与MRI兼容的力平台来模拟主动平衡控制。11名健康受试者(平均年龄75+/-5岁)进行了一项主动平衡模拟任务，使用视觉反馈来控制踝背屈肌(OF)和趾屈肌(PF)运动产生的前后压力中心运动，模式与直立姿势控制一致。另外还进行了一项踝关节DF/PF用力任务。在主动平衡模拟和踝关节DF/PF任务中，双侧梭状回和颞中回、右侧额下回、额中回和额上回均被激活。与主动平衡模拟任务相比，在踝部DF/PF任务中没有发现更活跃的区域。与踝部df/pf任务相比，主动平衡模拟任务在颞中、上回、岛叶，以及覆盖穹隆体区、额上回、额内侧回、扣带前核和尾状核的大簇中，被激活程度更高。这项研究证明了在磁共振成像过程中使用力平台模拟主动平衡控制的实用性，其在大脑皮层区域引起的活动与对主动平衡和平衡心理意象的研究一致。(C)2014爱思唯尔B.V.保留所有权利。
Human postural control, which relies on information from vestibular, visual, and proprioceptive inputs, degrades with aging, and falls are the leading cause of injury in older adults. In the last decade, functional neuroimaging studies have been performed in order to gain a greater understanding of the supraspinal control of balance and walking. It is known that active balancing involves cortical and subcortical structures in the brain, but neuroimaging of the brain during these tasks has been limited. The study of the effect of aging on the functional neuroimaging of posture and gait has only recently been undertaken. In this study, an MRI-compatible force platform was developed to simulate active balance control. Eleven healthy participants (mean age 75 +/- 5 yr) performed an active balance simulation task by using visual feedback to control anterior-posterior center of pressure movements generated by ankle dorsiflexor (OF) and plantarflexor (PF) movements, in a pattern consistent with upright stance control. An additional ankle DF/PF exertion task was performed. During both the active balance simulation and the ankle DF/PF tasks, the bilateral fusiforrn gyrus and middle temporal gyrus, right inferior, middle, and superior frontal gyrii were activated. No areas were found to be more active during the ankle DF/PF task when compared with the active balance simulation task. When compared to the ankle DF/PF task, the active balance simulation task elicited greater activation in the middle and superior temporal gyrii, insula, and a large cluster that covered the corpus callosum, superior and medial frontal gyrii, as well as the anterior cingulate and caudate nucleus. This study demonstrates the utility in using a force platform to simulate active balance control during MR imaging that elicits activity in cortical regions consistent with studies of active balance and mental imagery of balance. (c) 2014 Elsevier B.V. All rights reserved.