Structure-activity relationship of antibacterial chalcones
Structure-activity relationship of antibacterial chalcones
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DOI：
10.1016/j.bmc.2008.09.064
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发表时间：
2008-11-15
影响因子：
3.5
通讯作者：
Junior, Artur Smania
中科院分区：
文献类型：
--
作者：
Avila, Hugo Pereira;Albino Smania, Elza de Fatima;Junior, Artur Smania
测定31种查尔酮对蜡样芽孢杆菌ATCC 11778、大肠杆菌ATCC 25922、铜绿假单胞菌ATCC 27853和金黄色葡萄球菌ATCC 25923的抑菌活性。一些查尔酮对革兰氏阳性菌具有相当显著的活性。通过比较得到的结果，抗菌活性可能与C-4羟基、C-4‘含氧取代基或C-3’类异戊二烯侧链的存在等特征有关，而C-2'羟基可能对分子的稳定性有重要影响。查尔酮对人类病原微生物的抑制作用可能与其芳烃环的取代模式有关。(C) 2008 Elsevier Ltd版权所有。
The antibacterial activity of 31 chalcones was tested against bacterial strains, Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 25923. Some of the tested chalcones showed fair to significant activity against Gram-positive bacteria. By comparison of the results obtained, the antibacterial activity can be related to features such as the presence of a C-4 hydroxyl group, a C-4' oxygenated substituent or a C-3' isoprenoid side chain, while the C-2' hydroxyl group might have importance for the stability of the molecule. The inhibitory effect of chalcones on human pathogenic microorganisms can be correlated with the substitution patterns of the aromatics rings. (C) 2008 Elsevier Ltd. All rights reserved.