STRUCTURAL CHARACTERISTICS OF AN ANTIGEN REQUIRED FOR ITS INTERACTION WITH IA AND RECOGNITION BY T-CELLS
STRUCTURAL CHARACTERISTICS OF AN ANTIGEN REQUIRED FOR ITS INTERACTION WITH IA AND RECOGNITION BY T-CELLS
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DOI：
10.1038/328395a0
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发表时间：
1987-07-30
期刊：
影响因子：
64.8
通讯作者：
GREY, HM
中科院分区：
文献类型：
--
作者：
SETTE, A;BUUS, S;GREY, HM
详细分析了免疫原性肽内的残基，这些残基赋予了它与Ia相互作用并被T细胞识别的能力。Ia仅与少数肽残基相互作用，总体上表现出非常广泛的特异性。一些残基似乎与Ia和T细胞相互作用，导致一种肽抗原“夹”在Ia和T细胞受体之间的模型。
A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.