Multimodal Architectonic Subdivision of the Rostral Part (Area F5) of the Macaque Ventral Premotor Cortex
Multimodal Architectonic Subdivision of the Rostral Part (Area F5) of the Macaque Ventral Premotor Cortex
复制标题
DOI：
10.1002/cne.21892
复制
发表时间：
2009-01-10
影响因子：
2.5
通讯作者：
Luppino, Giuseppe
中科院分区：
文献类型：
--
作者：
Belmalih, Abdelouahed;Borra, Elena;Luppino, Giuseppe
我们使用细胞、骨髓和化学结构（SMI-32和calbindin免疫反应性的分布）方法来评估腹侧运动前皮质（PMv）的吻侧组织化学区F5是否包含结构不同的区域，可能对应于功能不同的领域。确定了三个区域，占据F5的不同部分。一个区域，被称为“凸”F5 (F5c)，延伸到星状后凸皮层上，毗邻下弓状沟，其细胞结构特征是层状外观很差，这是由于整个细胞群在大小和密度上相当均匀。另外两个区域，分别为F5的“后”和“前”（分别为F5p和F5a），位于不同的前后水平，位于星状后侧壁内。F5p的主要细胞结构特征是细胞大小和密度相对均匀的III层，细胞致密的Va层，以及在Vb层中存在较大的金字塔。F5a的主要细胞结构特征是在最低的III层存在较大的金字塔和突出的同质层v。此外，我们的研究结果表明，F5c和F5p与尾端PMv区相邻，对应于F4的组织化学区，这为猕猴PMv分为尾端和吻端，分别对应于F4和F5复合体提供了额外的证据。目前的数据，连同其他功能和连接数据，表明三个吻侧PMv区域F5p， F5a和F5c对应于不同的皮层实体，可能涉及运动控制和认知运动功能的不同方面。[j] .中国生物医学工程学报，2009。(C) 2008 Wiley-Liss, Inc。
We used a cyto-, myelo-, and chemoarchitectonic (distribution of SMI-32 and calbindin immunoreactivity) approach to assess whether the rostral histochemical area F5 of the ventral premotor cortex (PMv) comprises architectonically distinct areas, possibly corresponding to functionally different fields. Three areas were identified, occupying different parts of F5. One area, designated as "convexity" F5 (F5c), extends on the postarcuate convexity cortex adjacent to the inferior arcuate sulcus and is characterized, cytoarchitectonically, by a poorly laminated appearance, resulting from an overall cell population rather homogeneous in size and density. The other two areas, designated as "posterior" and "anterior" F5 (F5p and F5a, respectively), lie within the postarcuate bank at different anteroposterior levels. Major cytoarchitectonic features of F5p are a layer III relatively homogeneous in cell size and density, a cell-dense layer Va, and the presence of relatively large pyramids in layer Vb. Major cytoarchitectonic features of F5a are the presence of relatively large pyramids in lowest layer III and a prominent, homogenous layer V. Furthermore, our results showed that F5c and F5p border caudally with a caudal PMv area corresponding to histochemical area F4, providing additional evidence for a general subdivision of the macaque PMv into a caudal and a rostral part, corresponding to F4 and to the F5 complex, respectively. The present data, together with other functional and connectional data, suggest that the three rostral PMv areas F5p, F5a, and F5c correspond to distinct cortical entities, possibly involved in different aspects of motor control and cognitive motor functions. J. Comp. Neurol. 512:183-217, 2009. (C) 2008 Wiley-Liss, Inc.