Biocatalytic production of tetrahydroisoquinolines.
Biocatalytic production of tetrahydroisoquinolines.
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DOI：
10.1016/j.tetlet.2011.12.089
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发表时间：
2012-02-29
影响因子：
1.8
通讯作者：
O'Connor SE
中科院分区：
文献类型：
--
作者：
Ruff BM;Bräse S;O'Connor SE
描述了去甲乌药碱合酶的混杂性。这种生物催化剂通过在Pictet-Spengler反应中使多巴胺与各种乙醛环化而产生各种各样的取代的四氢异喹啉。这种酶促反应可以提供一系列四氢异喹啉生物碱的生物催化途径。
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.