Menopausal symptoms in women with premature ovarian insufficiency: prevalence, severity, and associated factors
Menopausal symptoms in women with premature ovarian insufficiency: prevalence, severity, and associated factors
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卵巢早衰女性的更年期症状：患病率、严重程度和相关因素
DOI：
10.1097/gme.0000000000001733
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发表时间：
2021
影响因子：
2.7
通讯作者：
Zhou Jianhong
中科院分区：
文献类型：
--
作者：
Huang Yizhou;Qi Tongyun;Ma Linjuan;Li Die;Li Chunming;Lan Yibing;Chu Ketan;Chen Peiqiong;Xu Wenxian;Cao Yina;Ying Qian;Xu Ling;Zhou Jianhong
目的：全面调查和评价卵巢功能不全（POI）妇女绝经期症状的发生率、严重程度及相关因素。在这项研究中，具体的绝经期妇女经历的POI和妇女自然绝经women were compared.Methods：在这项横断面研究中，293中国妇女POI从门诊招募2014年6月至2019年1月。采用改良Kupperman月经指数评估绝经期症状的患病率和严重程度。参与者完成了一份结构化问卷，包括病史，月经特征和社会人口学数据。结果：293例POI患者（33.76±5.47岁）中，最常见的症状为情绪波动（73.4%）、失眠（58.7%）、性功能障碍（58.7%）和疲劳（57.3%）。最常报告的是中度至重度情绪波动（23.9%），其次是蚁化（17.4%）和潮热/出汗（17.1%）。与自然绝经的女性相比，POI女性表现出明显更高的疲劳风险（比值比= 1.42; 95%置信区间，1.04-1.94），（3.12; 1.94-5.01）、情绪波动（3.57; 2.33-5.45），失眠（1.41; 1.02-1.96），并显著降低中度至重度性问题的风险（0.40; 0.23-0.69）、任何和中度至重度肌肉/关节疼痛（分别为0.41; 0.27-0.62和0.45; 0.25-0.78）。生活在城市地区和较高的妊娠率与绝经期症状的妇女POI.Conclusions：妇女POI经历了一个高患病率的绝经期症状，特别是与心理和性领域。此外，与自然绝经的妇女相比，POI妇女往往有更多令人痛苦的更年期症状。
Objective:To comprehensively investigate and evaluate the prevalence, severity, and associated factors of menopausal symptoms in women with premature ovarian insufficiency (POI). In this study, the specific symptomatology experienced by women with POI and women with natural menopause was also compared.Methods:In this cross-sectional study, 293 Chinese women with POI from an outpatient clinic were recruited between June 2014 and January 2019. The prevalence and severity of menopausal symptoms were assessed with modified Kupperman Menopausal Index. Participants completed a structured questionnaire, including medical history, menstrual characteristics, and sociodemographic data. Serum levels of reproductive hormones were measured.Results:Among 293 women with POI (33.76±5.47 y), the most prevalent symptoms were mood swings (73.4%), insomnia (58.7%), sexual problems (58.7%), and fatigue (57.3%). Moderate-to-severe mood swings were most frequently reported (23.9%), followed by formication (17.4%) and hot flashes/sweating (17.1%). Compared with women with natural menopause, women with POI exhibited significantly higher risks for fatigue (odds ratio= 1.42; 95% confidence interval, 1.04-1.94), melancholia (3.12; 1.94-5.01), mood swings (3.57; 2.33-5.45), insomnia (1.41; 1.02-1.96), and significantly lower risks for moderate-to-severe sexual problems (0.40; 0.23-0.69), any and moderate-to-severe muscle/joint pain (0.41; 0.27-0.62 and 0.45; 0.25-0.78, respectively). Living in urban areas and higher gravidity were independently associated with menopausal symptoms in women with POI.Conclusions:Women with POI experienced a high prevalence of menopausal symptoms, particularly related to psychological and sexual domains. Furthermore, women with POI tended to have more distressing menopausal symptoms compared with women with natural menopause.