Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys
Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys
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含铜钛合金的生物相容性和铜离子释放动力学
DOI：
10.1016/j.jmst.2021.03.074
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发表时间：
2021
影响因子：
10.9
通讯作者：
Qi Xun
中科院分区：
文献类型：
--
作者：
Ren Ling;Xu Xiaohe;Liu Hui;Yang Ke;Qi Xun
为了降低种植体相关感染的风险，我们设计开发了一系列医用含铜钛合金，通过释放铜离子发挥抗菌作用，但铜含量过高和不足都会对人体健康产生不利影响;因此，本发明提供了一种方法，本研究的目的是综合评价含铜钛合金的短期和长期生物安全性（Ti6 Al 4V-Cu和Ti-Cu）的体外和体内的研究。此外，结果表明，含铜钛合金的生物相容性符合ISO标准的要求，在正常的零应力状态下，含铜钛合金的铜离子释放动力学在整个时间段内表现出良好的相关性。顺序模型，释放速率几乎恒定。释放速率保持在对人类安全的十亿分之一水平;因此，我们可以得出结论，我们的含铜钛合金具有令人满意的生物相容性。
To reduce the risk of implant-associated infections,we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role.However,both excessive and deficient Cu levels adversely affect human health;therefore,the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo.Moreover,the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated.The results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate.The release rate maintained at a parts per billion level safe for humans;consequently,we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility.