Human papillomavirus genotype distribution among HPV-positive women in Sichuan province, Southwest China.
Human papillomavirus genotype distribution among HPV-positive women in Sichuan province, Southwest China.
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中国西南部四川省 HPV 阳性女性人乳头瘤病毒基因型分布。
DOI：
10.1007/s00705-017-3556-1
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发表时间：
2018
期刊：
影响因子：
4.8
通讯作者：
Miao He
中科院分区：
文献类型：
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作者：
Tao Guo;Yaling Gao;Zhan Gao;Pu Liao;Miao He
本研究以医院为基础，对四川省4,305例妇科患者进行了人乳头瘤病毒（HPV）基因型分布调查。2014年3月至2015年3月期间，在妇科诊所就诊的女性在知情同意后接受HPV筛查。宫颈刮片进行细胞病理学检查和阴道镜直接活检。在Luminex 200系统上进行HPV基因分型。17种高风险（HR）基因型（HPV-16、-18、-31、-33、-35、-39、-45、-51、-52、-53、-56、-58、-59、-66、-68、-73和-82）和七种低风险（LR）基因型HPV-6、-11、-42、-43、-61、-81和-83型。在所有HPV阳性妇女中，34.1%（1，467/4，305）的病例显示细胞学和活检异常，包括高度鳞状病变（HSIL），宫颈上皮内瘤变2级和3级（CIN 2/CIN 3），宫颈癌（CC）。HPV-16、-52和-58是主要的基因型，其次是HPV-56、-18、-59、-39、-53、-33和-81。共有3，785名（87.9%）HPV阳性妇女被发现有HR HPV感染，而859名（20.0%）被发现有LR HPV感染。在所有患者中，79%（3，401/4，305）感染了单一株HPV，其中85.5%（2，907/3，401）病例为HR HPV基因型。在宫颈癌前病变（CPLs）和CC患者中，HRHPV-16、-58、-52、-33和-18是主要的基因型。有趣的是，33名CPL患者有HPV-61、-11、-81、-6、-43或-42的单一LR HPV感染。此外，1例CC患者仅感染LR HPV-11。根据四川地区HPV基因型多样性丰富的特点，我们建议开展大规模的流行病学调查，不仅要了解HPV基因型的分布情况，还要为HPV疫苗接种计划提供所需信息，预测西南地区现有疫苗的有效性。
In this hospital-based descriptive study, the genotype distribution of human papillomavirus (HPV) among HPV-infected women were investigated in 4,305 gynecological patients in Sichuan province. Females attending gynecology clinics between March 2014 and March 2015 were subjected to HPV screening after giving informed consent. Cervical scrapings were examined by cytopathology and colposcopy-directed biopsies. HPV genotyping was performed on a Luminex 200 system. Seventeen high-risk (HR) genotypes (HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -53, -56, -58, -59, -66, -68, -73, and -82) and seven low-risk (LR) genotypes (HPV-6, -11, -42, -43, -61, -81, and -83) were detected. Among all HPV-positive women, 34.1% (1,467/4,305) of the cases showed abnormal cytology and biopsy, including high-grade squamous lesions (HSIL), cervical intraepithelial neoplasias of grades 2 and 3 (CIN2/CIN3), and cervical cancer (CC). HPV-16, -52, and -58 were the predominant genotypes, followed by HPV-56, -18, -59, -39, -53, -33, and -81. A total of 3,785 (87.9%) HPV positive women were found to have HR HPV infection, while 859 (20.0%) were found to have LR HPV infection. Among all patients, 79% (3,401/4,305) were infected with a single strain of HPV, 85.5% (2,907/3,401) cases of which were of the HR HPV genotype. In cervical precancerous lesions (CPLs) and CC patients, HR HPV-16, -58, -52, -33, and -18 were the predominant genotypes. Interestingly, 33 CPL patients had a single LR HPV infection with HPV-61, -11, -81, -6, -43, or -42. Furthermore, one CC patient was infected only with LR HPV-11. According to the abundant genotype diversity of HPV in Sichuan, we suggest that a large-scale epidemiological investigation should be launched, not only to understand the distribution of HPV genotype, but also to provide information needed for HPV vaccination programs and to predict the effectiveness of current vaccines in Southwest China.