Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson's disease patient with RAB39B gene mutation.
Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson's disease patient with RAB39B gene mutation.
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DOI：
10.1016/j.scr.2021.102454
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发表时间：
2021-07
影响因子：
1.2
通讯作者：
Huifang Sun;Zhuoya Wang;Qi Zhang;Yu-tao Liu;Jing Yang;Han Liu;Changhe Shi;Yan-lin Wang;Yuming Xu
中科院分区：
文献类型：
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作者：
Huifang Sun;Zhuoya Wang;Qi Zhang;Yu-tao Liu;Jing Yang;Han Liu;Changhe Shi;Yan-lin Wang;Yuming Xu
Parkinson's disease is a common neurogenetic degenerative disease that can be caused by a variety of genetic mutations. RAB39B gene mutations have recently been identified as a cause of Parkinson's disease. We collected skin tissue samples from a family with mutations in RAB39B for our clinical study. Additionally, we constructed patient-derived induced pluripotent stem cells (iPSCs) from the patient’s uncle using an unintegrated reprogramming plasmid transfection method to create a reliable cell model for the subsequent study of Parkinson's disease.
