Neuronal activity patterns in primate primary motor cortex related to trained or semiautomatic jaw and tongue movements
Neuronal activity patterns in primate primary motor cortex related to trained or semiautomatic jaw and tongue movements
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DOI：
10.1152/jn.2002.87.5.2531
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发表时间：
2002-05-01
影响因子：
2.5
通讯作者：
Sessle, BJ
中科院分区：
文献类型：
--
作者：
Yao, DY;Yamamura, K;Sessle, BJ
本研究进行，以确定在清醒的猴子的咀嚼和其他orofacial运动的面部初级运动皮层（面MI）内的神经元的放电模式和机械感受野（RF）的属性。在总共记录的107个面部MI神经元中，74个测试的73个具有与咀嚼相关的活动，66个测试的神经元中的47个显示出与训练的舌头任务相关的活动。在73个咀嚼相关神经元中，52个（71.2%）在节律性咀嚼过程中表现出明显的节律性活动。共有32例（43.8%）患者吞咽固体食物（苹果）时的活动也发生了显著变化。许多咀嚼相关的神经元（81.8%的55个测试）有一个orofacial RF，其中大多数是在舌背。舌前伸是由皮层内微刺激（ICMS）在大多数（63.6%）的记录点，其中神经元在有节奏的下颌打开阶段，而舌回缩引起的ICMS在大多数（66.7%）的网站，其中神经元在有节奏的下颌关闭阶段被记录。在47个任务相关神经元中，22个中的21个（95.5%）也显示出咀嚼相关的活动，29个（61.7%）表现出与吞咽果汁奖励相关的活动的显着变化。在与咀嚼、吞咽或任务相关的神经元活动中，峰值放电频率没有显著差异。这些研究结果提供了进一步的证据，面MI可能发挥重要作用，不仅在训练有素的orofacial运动，但也在咀嚼以及吞咽，包括控制舌头和下颌运动发生在咀嚼序列。
The present study was undertaken to determine the firing patterns and the mechanoreceptive field (RF) properties of neurons within the face primary motor cortex (face-MI) in relation to chewing and other orofacial movements in the awake monkey. Of a total of 107 face-MI neurons recorded, 73 of 74 tested had activity related to chewing and 47 of 66 neurons tested showed activity related to a trained tongue task. Of the 73 chewing-related neurons, 52 (71.2%) showed clear rhythmic activity during rhythmic chewing. A total of 32 (43.8%) also showed significant alterations in activity in relation to the swallowing of a solid food (apple) bolus. Many of the chewing-related neurons (81.8% of 55 tested) had an orofacial RF, which for most was on the tongue dorsum. Tongue protrusion was evoked by intracortical microstimulation (ICMS) at most (63.6%) of the recording sites where neurons fired during the rhythmic jaw-opening phase, whereas tongue retraction was evoked by ICMS at most (66.7%) sites at which the neurons firing during the rhythmic jaw-closing phase were recorded. Of the 47 task-related neurons, 21 of 22 (95.5%) examined also showed chewing-related activity and 29 (61.7%) demonstrated significant alteration in activity in relation to the swallowing of a juice reward. There were no significant differences in the peak firing frequency among neuronal activities related to chewing, swallowing, or the task. These findings provide further evidence that face-MI may play an important role not only in trained orofacial movements but also in chewing as well as swallowing, including the control of tongue and jaw movements that occur during the masticatory sequence.