Volumetric White Matter Hyperintensity Ranges Correspond to Fazekas Scores on Brain MRI
Volumetric White Matter Hyperintensity Ranges Correspond to Fazekas Scores on Brain MRI
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DOI：
10.1016/j.jstrokecerebrovasdis.2022.106333
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发表时间：
2022-02-11
影响因子：
2.5
通讯作者：
Cutting, Shawna
中科院分区：
文献类型：
--
作者：
Andere, Ariana;Jindal, Gaurav;Cutting, Shawna
简介：白色高信号（WMH）是MRI上显示的深部和皮质下白色物质中的异常T2信号，与高血压、脑血管疾病和衰老有关。Fazekas（Fz）评分系统是评估WMH严重程度的常用定性工具。虽然研究比较了Fazekas评分与其他评分方法，但尚未研究使用当前半自动体积技术比较Fazekas评分和WMH体积。方法：我们回顾了2015年至2017年期间在我们机构获得的MRI研究。由一名接受过Fazekas评分培训的作者对相对WMH进行评分。一位委员会认证的神经放射科医生独立地对他们进行了评分以供确认。使用3D Slicer 4.9完成WMH的手动分割。形成3D模型以定量WMH，单位为毫升（mL）。进行ANOVA检验以确定Fazekas评分与相应WMH体积的相关性。结果：在198例患者中，163例显示WMH（Fz 1：n=66; Fz 2：n=49; Fz 3：n=48）。根据Fazekas评分，WMH体积存在显著差异（F = 141.1，p
Introduction: White matter hyperintensity (WMH) is an abnormal T2 signal in the deep and subcortical white matter visualized on MRI associated with hypertension, cerebrovascular disease, and aging. The Fazekas (Fz) scoring system is a commonly used qualitative tool to assess the severity of WMH. While studies have compared Fazekas scores to other scoring methods, the comparison of Fazekas scores and volume of WMH using current semiautomated volumetric techniques has not been studied. Methods: We reviewed MRI studies acquired at our institution between 2015 and 2017. Relative WMH was scored by one author trained in Fazekas scoring. A board certified neuroradiologist scored them independently for confirmation. Manual segmentations of WMH were completed using 3D Slicer 4.9. A 3D model was formed to quantify WMH in milliliters (mL). ANOVA tests were performed to determine the association of Fazekas scores with corresponding WMH volumes. Results: Among the 198 patients in our study, WMH were visualized in 163 (Fz1: n=66; Fz2: n=49; Fz3: n=48). WMH volumes significantly differed according to Fazekas score (F = 141.1, p