Fractal dimension in human cortical surface: Multiple regression analysis with cortical thickness, sulcal depth, and folding area
Fractal dimension in human cortical surface: Multiple regression analysis with cortical thickness, sulcal depth, and folding area
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DOI：
10.1002/hbm.20238
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发表时间：
2006-12-01
影响因子：
4.8
通讯作者：
Kim, Sun I.
中科院分区：
文献类型：
--
作者：
Im, Kiho;Lee, Jong-Min;Kim, Sun I.
分维(FD)已被广泛用于定量描述大脑皮层的结构复杂性。FD是形状复杂性的一种非常紧凑的度量，它将所有细节浓缩为一个单独的数值。我们通过与皮质厚度、沟深度和折叠面积相关的多元回归分析，解释了正常对照组皮质表面FD的变化。我们使用了一个皮质表面，显示了折叠回的可靠表示，并手动将其划分为额区、顶区、颞区和枕区进行区域分析。在两个半球，平均皮质厚度和折叠面积对皮质复杂性表现出显着的联合效应，约占其方差的50%。褶皱面积对皮质表面的Fd有显著影响，在两个半球和多个脑叶区域均为正系数，而沟深度仅在左侧颞区显著。这些结果可能表明，人的大脑皮质是通过皮质厚度变薄、褶皱频率增加和脑回形状的卷曲而不是通过加深脑沟区域而形成复杂的结构。通过Fd与智商和受教育年限的相关分析，结果表明皮质表面的复杂形状与智力和教育程度有显著的关系。我们的发现可能揭示了人脑FD增加时大脑皮层的结构特征，并为脑发育提供重要信息。
Fractal dimension (FD) has been widely used to provide a quantitative description of structural complexity in the cerebral cortex. FD is an extremely compact measure of shape complexity, condensing all details into a single numeric value. We interpreted the variation of the FD in the cortical surface of normal controls through multiple regression analysis with cortical thickness, sulcal depth, and folding area related to cortical complexity. We used a cortical surface showing a reliable representation of folded gyri and manually parcellated it into frontal, parietal, temporal, and occipital regions for regional analysis. In both hemispheres the mean cortical thickness and folding area showed significant combination effects on cortical complexity and accounted for about 50% of its variance. The folding area was significant in accounting for the FD of the cortical surface, with positive coefficients in both hemispheres and several lobe regions, while sulcal depth was significant only in the left temporal region. The results may suggest that human cortex develops a complex structure through the thinning of cortical thickness and by increasing the frequency of folds and the convolution of gyral shape rather than by deepening sulcal regions. Through correlation analysis of FD) with IQ and the number of years of education, the results showed that a complex shape of the cortical surface has a significant relationship with intelligence and education. Our findings may indicate the structural characteristics that are revealed in the cerebral cortex when the FD) in human brain is increased, and provide important information about brain development.