Urinary calcium excretion in severe preeclampsia and eclampsia
Urinary calcium excretion in severe preeclampsia and eclampsia
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DOI：
10.1515/cclm.2006.010
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发表时间：
2006-01-01
影响因子：
6.8
通讯作者：
Kadanali, S
中科院分区：
文献类型：
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作者：
Ingec, M;Nazik, H;Kadanali, S
本研究对轻度子痫前期、重度子痫前期和子痫患者的尿钙水平进行了评价。我们收集了35名轻度先兆子痫患者（第1组）、30名重度先兆子痫患者（第2组）和17名子痫患者（第3组）的24小时尿液样本。对照组（第4组）为35例健康孕妇。测定血清总钙、肌酐和尿钙水平。这些值在四个组中进行比较。所有组的平均产妇年龄和产次相似。血清总钙和肌酐水平差异无统计学意义（p > 0.05）。子痫前期和子痫患者尿钙排泄量显著低于对照组（p > 0.0001）。轻度子痫前期组与重度子痫前期组、重度子痫前期组与子痫组尿钙水平无显著性差异（P > 0.05），但子痫组尿钙水平低于轻度子痫前期组（P < 0.05）。总之，重度子痫前期或子痫患者尿钙排泄减少。然而，尿钙排泄的减少不能用来确定先兆子痫的严重程度，或预测即将发生的子痫。
Urinary calcium levels in women with mild preeclampsia, severe preeclampsia and eclampsia were evaluated in this study. We collected 24-h urine samples from 35 mild preeclamptic (Group 1), 30 severe preeclamptic (Group 2), and 17 eclamptic patients (Group 3). The control group (Group 4) consisted of 35 healthy pregnant women. Serum levels of total calcium and creatinine, and urinary calcium were measured. These values were compared in the four groups. The mean maternal age and parity were similar in all groups. There were no statistically significant differences in the serum levels of total calcium and creatinine (p > 0.05). Urinary calcium excretion in patients with preeclampsia and eclampsia was significantly lower than in controls (p > 0.0001). Urinary calcium levels between mild preeclampsia and severe preeclampsia, and severe preeclampsia and eclampsia were similar (p > 0.05), but were lower in eclampsia than in mild preeclampsia (p < 0.05). In conclusion, urinary calcium excretion is reduced in patients with severe preeclampsia or eclampsia. However, the decrease in urinary calcium excretion cannot be used to identify the severity of preeclampsia, or to predict impending eclampsia.