Long-term modulation of respiratory network activity following anoxia in vitro
Long-term modulation of respiratory network activity following anoxia in vitro
复制标题
DOI：
10.1152/jn.2002.87.6.2964
复制
发表时间：
2002-06-01
影响因子：
2.5
通讯作者：
Ramirez, JM
中科院分区：
文献类型：
--
作者：
Blitz, DM;Ramirez, JM
产生节律行为的神经网络需要灵活性来响应动物内部和外部状态的变化。重要的是不仅要了解网络在这种扰动期间如何响应，还要了解网络如何恢复。例如，呼吸网络需要对睡眠、运动和呼吸障碍期间可能发生的氧气水平的暂时变化做出反应并从中恢复。在氧气水平暂时下降期间，呼吸频率增加，随后出现抑郁，可导致完全呼吸暂停。在这里，我们使用小鼠脑干切片制备作为模型系统，以检查短暂缺氧后呼吸网络活动的恢复。我们发现，呼吸网络恢复从一个单一的缺氧事件与一个短暂的增加虚构的呼吸频率。尽管反复缺氧不会引起更大的频率增加，但它确实引起持续时间小于或等于90 min的持续时间更长的频率增加。因此，氧水平降低对呼吸网络有中枢介导的长期影响。这种调制发生作为一个短暂的重复，但不是单一的缺氧暴露后，虚构的呼吸频率的延长促进。这些数据是重要的，以考虑在疾病的背景下，如睡眠呼吸暂停，其中短暂的周期性缺氧发作的经验。
Neural networks that produce rhythmic behaviors require flexibility to respond to changes in the internal and external state of the animal. It is important to not only understand how a network responds during such perturbations but also how the network recovers. For example, the respiratory network needs to respond to and recover from temporary changes in oxygen level that can occur during sleep, exercise, and respiratory disorders. During a temporary decrease in oxygen level, there is an increase in respiratory frequency followed by a depression that can lead to complete apnea. Here we used a mouse brain stem slice preparation as a model system to examine the recovery of respiratory network activity after brief episodes of anoxia. We found the respiratory network recovers from a single anoxic episode with a transient increase in fictive respiratory frequency. Although repetitive anoxia does not elicit a greater frequency increase, it does elicit a longer lasting frequency increase persisting less than or equal to90 min. Thus there is a centrally mediated long-lasting influence on the respiratory network elicited by decreased oxygen levels. This modulation occurs as a prolonged facilitation of fictive respiratory frequency after brief repetitive but not single anoxic exposure. These data are important to consider in the context of disorders such as sleep apnea in which brief periodic anoxic episodes are experienced.