EFFECT OF DIABETES AND INSULIN ON ACTIVITY OF MYOCARDIAL AND ADIPOSE TISSUE LIPOPROTEIN LIPASE OF RATS
EFFECT OF DIABETES AND INSULIN ON ACTIVITY OF MYOCARDIAL AND ADIPOSE TISSUE LIPOPROTEIN LIPASE OF RATS
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DOI：
10.1172/jci104722
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发表时间：
1963-01-01
影响因子：
15.9
通讯作者：
KESSLER, JI
中科院分区：
文献类型：
--
作者：
KESSLER, JI
比较正常、糖尿病和胰岛素治疗糖尿病大鼠心肌和附睾脂肪组织脂蛋白脂酶（LPL）活性。在正常大鼠中，脂肪组织的LPL活性显著高于心肌的活性。糖尿病引起脂肪组织LPL活性降低，心肌LPL活性显著升高。给糖尿病动物注射胰岛素可使两种组织的LPL活性恢复正常。的可能性，在组织中的酶活性的变化，产生的碳水化合物赤字，可能是一种机制，用于转移能量丰富的脂肪酸从仓库到心脏进行了讨论。
The lipoprotein lipase (LPL) activity of myocardial and epididymal fat tissue of normal, diabetic, and insulin-treated diabetic rats was compared. In normal rats the LPL activity of adipose tissue was considerably higher than the activity of the myocardium. Diabetes produced a decrease in the LPL activity of adipose tissue and a marked elevation of the myocardial LPL activity. Administration of insulin to the diabetic animals restored the LPL activity of both tissues to normal. The possibility that changes of the enzymatic activity in the tissues, produced by carbohydrate deficit, may represent a mechanism for diverting energy-rich fatty acids from the depots to the heart is discussed.