Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy
Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy
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DOI：
10.1007/s12265-018-9794-0
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发表时间：
2018-06-01
影响因子：
3.4
通讯作者：
Shen, Yuqin
中科院分区：
文献类型：
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作者：
Chen, Zhisong;Yan, Wenwen;Shen, Yuqin
免疫激活和炎症参与慢性心力衰竭（CHF）的进展。Th17细胞和CD4+CD25+调节性T （Treg）细胞都来自幼稚的Th细胞，共享互惠的发育途径，但表现出相反的作用。我们假设Th17/Treg平衡在CHF患者中受损，而运动可以改善它。结扎左冠状动脉左前降支制备缺血性心肌病大鼠。训练组采用跑步机训练；流式细胞术检测Th17细胞显著升高，Treg细胞显著降低，ELISA检测外周血IL-6、IL-17、tnf - α水平明显升高。我们发现Th17/Treg平衡在CHF大鼠中受损，提示Th17/Treg失衡可能在CHF的发病机制中发挥作用。运动可以改善Th17/Treg失衡，改善CHF的心功能。
Immune activation and inflammation participate in the progression of chronic heart failure (CHF). Th17 cells and CD4+CD25+ regulatory T (Treg) cells both come from naive Th cells and share reciprocal development pathways but exhibit opposite effects. We hypothesized that the Th17/Treg balance was impaired in patients with CHF, and exercise can improve it. Rats with ischemic cardiomyopathy were prepared by ligaturing the left anterior descending branch of the left coronary artery. Rats in training group were trained with treadmill; Th17 cells increased significantly while Treg cells significantly decreased in s by flow cytometry, and the peripheral blood level of IL-6, IL-17, and TNF-alpha was obviously elevated by ELISA assay. We found that Th17/Treg balance is impaired in CHF rats, suggesting Th17/Treg imbalance potentially plays a role in the pathogenesis of CHF. Exercise can improve Th17/Treg imbalance, which also improves cardiac function of CHF.