Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series
Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series
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DOI：
10.1136/bmj.m606
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发表时间：
2020-02-19
影响因子：
105.7
通讯作者：
Li, Lan-Juan
中科院分区：
文献类型：
--
作者：
Xu, Xiao-Wei;Wu, Xiao-Xin;Li, Lan-Juan
目的研究浙江省2019年严重急性呼吸综合征冠状病毒2型（SARS-Cov-2）感染患者的临床特征。数据收集时间为2020年1月10日至2020年1月26日。主要结局指标使用标准化病例报告表收集的临床数据，如体温、暴露史、潜伏期。如果信息不清楚，杭州的工作组会联系负责治疗患者的医生进行澄清。在研究的62名患者中（中位年龄41岁），只有一名患者进入重症监护室，没有患者在研究期间死亡。根据研究，浙江省的感染者都没有接触过华南海鲜市场，这是病毒的原始来源;所有研究病例都是通过人与人之间的传播感染的。发病时最常见的症状为发热48例（77%），咳嗽50例（81%），咳痰35例（56%），头痛21例（34%），肌痛或疲劳32例（52%），腹泻3例（8%），咯血2例（3%）。只有2名患者（3%）在入院时出现呼吸急促。从暴露到发病的中位时间为4天（四分位距3-5天），从出现症状到首次入院的中位时间为2（1-4）天。结论截至2020年2月上旬，与武汉首次感染SARS-Cov-2的患者相比，浙江省患者的症状相对较轻。
OBJECTIVETo study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019).DESIGNRetrospective case series.SETTINGSeven hospitals in Zhejiang province, China.PARTICIPANTS62 patients admitted to hospital with laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 to 26 January 2020.MAIN OUTCOME MEASURESClinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. If information was not clear, the working group in Hangzhou contacted the doctor responsible for treating the patient for clarification.RESULTSOf the 62 patients studied (median age 41 years), only one was admitted to an intensive care unit, and no patients died during the study. According to research, none of the infected patients in Zhejiang province were ever exposed to the Huanan seafood market, the original source of the virus; all studied cases were infected by human to human transmission. The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). Only two patients (3%) developed shortness of breath on admission. The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days.CONCLUSIONAs of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild.