Echocardiographic changes after myocardial infarction in a model of left ventricular diastolic dysfunction.
Echocardiographic changes after myocardial infarction in a model of left ventricular diastolic dysfunction.
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DOI：
10.1152/ajpheart.1997.273.4.h2018
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发表时间：
1997-10
期刊：
影响因子：
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通讯作者：
G. Pennock;D. Yun;P. Agarwal;P. H. Spooner;S. Goldman
中科院分区：
文献类型：
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作者：
G. Pennock;D. Yun;P. Agarwal;P. H. Spooner;S. Goldman
为了确定梗死后兔子模型中心肌梗死对左心室 (LV) 舒张功能的早期和晚期影响，将雄性新西兰白兔随机分配进行回旋动脉结扎或假手术。在验证测量的再现性和可重复性后，在基线以及术后 1 小时和 3 周（每组 n = 10）对两组动物进行系列超声心动图和多普勒研究。梗死后 1 小时，观察到早期二尖瓣流入速度（E 波）和心房收缩时二尖瓣流入速度（A 波）降低，平均肺静脉收缩舒张比和 A 波反转速度增加，但左心室几何形状没有变化。梗塞后 3 周，二尖瓣 E-A 比值增加（1.1 ± 0.3 对比 2.9 ± 0.9，P < 0.001），左心房面积增加（131 ± 23 对比 510 ± 72 mm2，P < 0.001），肺静脉收缩与舒张比值下降（0.56 ± 0.20 vs. 0.79 ± 0.14，P = 0.008）与严重舒张异常（生理学受限）一致。这项研究的结果表明，兔子冠状动脉结扎提供了可重复的左心室舒张功能障碍的超声心动图和多普勒模型，该模型与在患有既往心肌梗塞、心力衰竭症状和保留左心室收缩功能的人类中发现的异常情况一致。
To determine the early and late effects of myocardial infarction on left ventricular (LV) diastolic function in the rabbit postinfarction model, male New Zealand White rabbits were randomly assigned to ligation of the circumflex artery or sham operation. Serial echocardiographic and Doppler studies were performed on both groups of animals at baseline and 1 h and 3 wk after surgery ( n = 10 for each group) after verification of the reproducibility and repeatability of the measurements. At 1 h postinfarction, decreases in early mitral inflow velocity (E wave) and mitral inflow velocity with atrial contraction (A wave) and increases in the mean pulmonary venous systolic-to-diastolic ratio and A wave reversal velocities were observed, without changes in LV geometry. By 3 wk postinfarction, increases in the mitral E-to-A ratio (1.1 ± 0.3 vs. 2.9 ± 0.9, P < 0.001) and left atrial area (131 ± 23 vs. 510 ± 72 mm2, P < 0.001) and decreases in the pulmonary venous systolic-to-diastolic ratio (0.56 ± 0.20 vs. 0.79 ± 0.14, P = 0.008) were consistent with severe diastolic abnormalities (restricted physiology). The findings of this study demonstrate that coronary artery ligation in the rabbit provides a reproducible echocardiographic and Doppler model of LV diastolic dysfunction that is consistent with abnormalities found in humans with previous myocardial infarction, symptoms of heart failure, and preserved LV systolic function.