A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance -based molds
A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance -based molds
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DOI：
10.1063/1.3242697
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发表时间：
2009-10-01
影响因子：
1.6
通讯作者：
Bernardo, Marcelino
中科院分区：
文献类型：
--
作者：
Shah, Vijay;Pohida, Thomas;Bernardo, Marcelino
提出了一种用于基于体内图像设计和快速制造患者特异性组织切片设备以便于将图像与组织病理学相关联的过程的方法。该方法适用于根治性乳房切除术标本，其中定制模具是使用术前获得的每个患者的磁共振（MR）图像设计的。在这种情况下，模具将前列腺保持在适当的位置，同时将具有单个刀片或多个刀片的刀插入槽中，所述槽被定位成获得与MR图像中的切片相对应的组织块。所得的组织学标本表现出良好的解剖相关性与MR图像。(C)2009年美国物理学会。[doi：10.1063/1.3242697]
A method for the design and rapid manufacture of a patient specific tissue slicing device based on in vivo images in order to facilitate the process of correlating the images with histopathology is presented. The method is applied to radical prostatectomy specimens where the customized mold is designed using magnetic resonance (MR) images of each patient obtained prior to surgery. In this case, the mold holds the prostate in place while a knife with a single blade or multiple blades is inserted in slots which are positioned to obtain tissue blocks corresponding to the slices in the MR images. The resulting histological specimens demonstrate good anatomical correlation with the MR images. (C) 2009 American Institute of Physics. [doi:10.1063/1.3242697]