Infant Formula Supplementation With Long-chain Polyunsaturated Fatty Acids Has No Effect on Bayley Developmental Scores at 18 Months of Age-IPD Meta-analysis of 4 Large Clinical Trials
Infant Formula Supplementation With Long-chain Polyunsaturated Fatty Acids Has No Effect on Bayley Developmental Scores at 18 Months of Age-IPD Meta-analysis of 4 Large Clinical Trials
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DOI：
10.1097/mpg.0b013e3181acae7d
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发表时间：
2010-01-01
影响因子：
2.9
通讯作者：
von Kries, Ruediger
中科院分区：
文献类型：
--
作者：
Beyerlein, Andreas;Hadders-Algra, Mijna;von Kries, Ruediger
目的：通过个体患者数据 (IPD) 荟萃分析，了解在配方奶中添加长链多不饱和脂肪酸 (LCPUFA) 是否会影响 18 个月大的足月儿或早产儿的神经发育。 材料和方法：来自 4 项含有和不含 LCPUFA 的配方奶的大型随机临床试验的 870 名儿童的数据，用于评估 LCPUFA 的效果 调整 针对早产儿、LCPUFA 来源和剂量的潜在混杂因素和广泛的亚组分析。任何其他检验 LCPUFA 补充剂对 18 个月婴儿贝利发育量表影响的临床试验都被认为是相关的。 MEDLINE 确定了两项相关研究，但我们无法获得。 IPD 荟萃分析通过早产、极低出生体重进行亚组分析（
Objectives: To find out whether supplementation of formula milk by long-chain polyunsaturated fatty acids (LCPUFA) affects neurodevelopment at 18 months of age in term or preterm infants by an individual patient data (IPD) meta-analysis.Materials and Methods: Data of 870 children from 4 large randomised clinical trials for formula milk with and without LCPUFAs allowed for assessing the effect of LCPUFA with adjustment For potential confounders and extensive subgroup analysis on prematurity, LCPUFA Source, and dosage. Any additional clinical trials examining the effect of LCPUFA supplementation on Bayley Scales of Infant Development at 18 months were regarded as relevant. Two relevant studies were identified by MEDLINE, but were not available to us. An IPD meta-analysis was performed with Subgroup analyses by preterm delivery, very low birth weight (