Plasma levels of interleukin-1-alpha in rheumatoid arthritis.
Plasma levels of interleukin-1-alpha in rheumatoid arthritis.
复制标题
类风湿性关节炎中白细胞介素 1-α 的血浆水平。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
G. Duff
中科院分区：
文献类型：
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作者：
J. Eastgate;J. Symons;N. Wood;S. Capper;G. Duff
白介素 1 β (IL-1 β) 被认为是类风湿性关节炎 (RA) 中的炎症介质，但人们对这种疾病中的相关细胞因子 IL-1 α 知之甚少。 IL-1 α 具有与 IL-1 β 相似的生物学特性，但与 IL-1 β 不同，它主要与细胞相关。在这项研究中，通过放射免疫测定法测量了 RA 患者和健康对照者的血浆 IL-1 α。将血浆水平与疾病活动的常规测量进行比较。两组的平均水平没有显着差异，并且在患者组 (n = 53) 内，唯一显着的横截面相关性是血浆 IL-1 α 和 ESR 之间。在纵向研究中，一些个体患者的血浆 IL-1 α 水平与不同的疾病活动指标相关。我们的结论是，虽然 IL-1 α 可能参与 RA 的免疫发病机制，但其在血浆中的测量似乎没有什么临床价值。
Interleukin-1-beta (IL-1 beta) has been implicated as an inflammatory mediator in rheumatoid arthritis (RA) but little is known about the related cytokine, IL-1 alpha, in this disease. IL-1 alpha has biological properties similar to IL-1 beta but, unlike IL-1 beta, remains mostly cell-associated. In this study plasma IL-1 alpha was measured by radioimmunoassay in patients with RA and in healthy controls. Plasma levels were compared with conventional measures of disease activity. The mean levels in the two groups were not significantly different and, within the patient group (n = 53), the only significant cross-sectional correlation was between plasma IL-1 alpha and ESR. In longitudinal studies, some individual patients had plasma IL-1 alpha levels that correlated with different measures of disease activity. We conclude that while IL-1 alpha may be involved in the immunopathogenesis of RA, its measurement in plasma seems to offer little of clinical value.