Relationship between social and cognitive functions in people with schizophrenia.
Relationship between social and cognitive functions in people with schizophrenia.
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DOI：
10.2147/ndt.s171207
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发表时间：
2018
影响因子：
3.2
通讯作者：
Ohmori T
中科院分区：
文献类型：
--
作者：
Tominaga T;Tomotake M;Takeda T;Ueoka Y;Tanaka T;Watanabe SY;Kameoka N;Nakataki M;Numata S;Izaki Y;Sumitani S;Kubo H;Kaneda Y;Ohmori T
本研究的目的是检查与精神分裂症患者社会功能相关的临床因素。参与者是 55 名病情稳定的精神分裂症门诊患者。他们的平均年龄为 39.36 (SD =10.65) 岁。使用生活质量量表（QLS）评估社会功能。通过精神分裂症共识认知电池（MCCB）改善认知的测量和治疗研究来评估认知功能。使用阳性和阴性症状量表（PANSS）、卡尔加里精神分裂症抑郁量表和药物诱发的锥体外系症状量表评估临床症状。 MCCB 认知领域得分和综合得分均与 QLS 得分无关。然而，在 10 个 MCCB 子测试中，轨迹制作测试 A 部分和精神分裂症符号编码认知简要评估 (BACS-SC) 分数与 QLS 分数呈正相关。在临床变量中，特别是PANSS阴性综合征量表评分与QLS评分具有很强的负相关性。逐步回归分析表明，PANSS 阴性症状量表评分是 QLS 评分的独立预测因子，尽管 BACS-SC 评分预测了 QLS 常见对象和活动分量表评分，但与 PANSS 阴性症状量表评分相比，相关性并不那么强。这些结果表明，BACS-SC 评估的处理速度可以预测社会功能的某些方面，但阴性症状对精神分裂症患者的整体社会功能有更大的影响。
The purpose of the present study was to examine clinical factors related to social function in people with schizophrenia. The participants were 55 stabilized outpatients with schizophrenia. Their mean age was 39.36 (SD =10.65) years. Social function was assessed using the Quality of Life Scale (QLS). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale. Neither the MCCB cognitive domain score nor composite score was correlated with the QLS scores. However, of the 10 MCCB subtests, the Trail Making Test Part A and the Brief Assessment of Cognition in Schizophrenia-Symbol Coding (BACS-SC) scores were positively correlated with the QLS scores. Among clinical variables, especially the PANSS negative syndrome scale score had a strong negative correlation with the QLS scores. Stepwise regression analyses showed that the PANSS negative syndrome scale score was an independent predictor of the QLS scores, and although the BACS-SC score predicted the QLS common objects and activities subscale score, the association was not so strong compared to the PANSS negative syndrome scale score. These results indicate that speed of processing evaluated by BACS-SC could predict some aspect of social function but negative symptoms have a much stronger impact on global social function in people with schizophrenia.