Depressive symptoms evaluated by the Calgary Depression Scale for Schizophrenia (CDSS): Genetic vulnerability and sex effects
Depressive symptoms evaluated by the Calgary Depression Scale for Schizophrenia (CDSS): Genetic vulnerability and sex effects
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DOI：
10.1016/j.psychres.2010.11.026
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发表时间：
2011-08-30
影响因子：
11.3
通讯作者：
Linares, Andres Ruiz
中科院分区：
文献类型：
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作者：
Martin-Reyes, Migdyrai;Mendoza, Raul;Linares, Andres Ruiz
本研究采用卡尔加里精神分裂症抑郁量表（CDSS）比较了多发性精神分裂症（MS）和单纯性精神分裂症（SS）患者抑郁症状的发生情况。采用阳性和阴性症状量表（PANSS）评定精神病理学。共对206例偏执型精神分裂症患者按DSM-IV标准进行了研究。采用遗传研究家庭访谈法（FIGS）对这些家庭进行研究。FIGs中精神分裂症阳性家族史的结果被称为MS（患者）：其缺失被称为SS（患者）。比较MS和SS患者的CDSS评分，并探讨组内和组间可能的性别差异。在对我们的样本（30）的分析中，精神分裂症患者中有19%患有抑郁症。抑郁症状的CDSS测量女性和MS男性组较高。MS组男性抑郁症状明显多于SS组。在这两组中女性没有发现差异。这项研究的结果强调了性别和家族史在理解精神分裂症异质性方面的重要性。这项研究表明，性别和熟悉的历史是重要的研究抑郁症症状的考虑。(C)2010爱思唯尔爱尔兰有限公司版权所有。
The present study compares the occurrence of depressive symptoms evaluated by the Calgary Depression Scale for Schizophrenia (CDSS) in patients of Multiplex (MS) and Simplex Schizophrenia families (SS). The Positive and Negative Syndrome Scale (PANSS) was used to evaluate psychopathology. A total of 206 paranoid schizophrenia patients were studied according DSM-IV criteria. The Family Interview for Genetic Studies (FIGS) was used to study the families. A result in the FIGS for a positive family history of schizophrenia was referred as MS (patients): its lack as SS (patients). CDSS scores were compared among MS and SS patients and possible sex differences intra- and inter-groups were explored. In the analysis of our sample (30) 19% of the total persons with schizophrenia group was depressed. The depressive symptoms measured by the CDSS were higher in females and the MS males group. Males from MS group showed more depressive symptoms than males from SS group. No differences with females from both groups were found. Findings in this study underscore the importance of gender and family history in understanding the heterogeneity of schizophrenia. This study suggests that sex and familiar history are important to consider in studying depressive symptoms. (C) 2010 Elsevier Ireland Ltd. All rights reserved.