Assessment of cumulative evidence on genetic associations: interim guidelines
Assessment of cumulative evidence on genetic associations: interim guidelines
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DOI：
10.1093/ije/dym159
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发表时间：
2008-02-01
影响因子：
7.7
通讯作者：
Khoury, Muin J.
中科院分区：
文献类型：
--
作者：
Ioannidis, John P.A.;Boffetta, Paolo;Khoury, Muin J.
流行病学研究中因果关系推断的既定准则可能不适用于遗传关联。一个共识的过程被用来制定指导标准，以评估遗传关联的累积流行病学证据。一个拟议的半定量指数分配三个级别的证据量，复制的程度，并防止偏见，也产生了强，中等或弱的流行病学可信度的综合评估。此外，我们还讨论了如何从生物数据中获得额外的输入和指导。未来的实证研究和共识的发展，需要开发一个综合模型相结合的流行病学和生物学证据在快速发展的遗传因素的调查领域。
Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of strong, moderate or weak epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.