A novel inert collagen matrix for hypospadias repair
A novel inert collagen matrix for hypospadias repair
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DOI：
10.1016/s0022-5347(01)68105-9
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发表时间：
1999-09-01
影响因子：
6.6
通讯作者：
Retik, AB
中科院分区：
文献类型：
--
作者：
Atala, A;Guzman, L;Retik, AB
目的：尿道下裂患者生殖道皮肤不足，尿道重建需要其他组织。虽然可以使用皮肤和粘膜移植，但它们可能增加住院率和发病率。我们探讨了使用膀胱粘膜下胶原惰性基质作为尿道修复的游离移植物替代物的可行性。材料与方法：对4例有尿道下裂病史的患者进行了多次尿道下裂修复术，采用基于胶原蛋白的惰性基质进行尿道重建。惰性胶原基质根据每位患者的需要修剪成大小。神经尿道是通过连续的6- 0聚乳酸缝合线将基质以嵌板的方式与尿道板吻合而形成的。所创造的神经thra大小从5到15厘米不等。结果：经过22个月的随访，4例患者中有3例在外观和功能方面取得了成功。其中一名患者的15厘米的神经管被创建有一个腺体下瘘。结论：使用胶原惰性基质似乎是有益的患者谁曾接受过尿道下裂修复和谁可能缺乏足够的生殖器皮肤重建。
Purpose: In select patients with hypospadias in whom genital skin is insufficient alternative tissues are needed for urethral reconstruction. Although skin and mucosal grafts may be used, they may increase hospitalization and morbidity. We explored the feasibility of using a bladder submucosal, collagen based inert matrix as a free graft substitute for urethral repair.Materials and Methods: Four patients with a history of hypospadias underwent repeat hypospadias repair using a collagen based inert matrix for urethral reconstruction. The inert collagen matrix was trimmed to size as needed for each patient. The neourethra was created by anastomosing the matrix in an onlay fashion to the urethral plate with continuous 6-zero polyglactin sutures. The created neourethra size ranged from 5 to 15 cm.Results: After a 22-month followup 3 of the 4 patients had a successful outcome in regard to cosmesis and function. One patient in whom a 15 cm. neourethra was created had a subglanular fistula.Conclusions: The use of a collagen inert matrix appears to be beneficial in patients who have undergone previous hypospadias repair and who may lack sufficient genital skin for reconstruction.