Notch signaling in blood vessels: from morphogenesis to homeostasis
Notch signaling in blood vessels: from morphogenesis to homeostasis
复制标题
血管中的Notch信号：从形态发生到稳态
DOI：
10.1007/s11427-014-4716-0
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Han Hua
中科院分区：
文献类型：
--
作者：
Yan XianChun;Chen Yan;Yang ZiYan;Han Hua
Notch信号通路是一种进化上保守的细胞间信号通路，在血管发育和生理中起着许多关键作用。令人信服的证据表明，Notch信号传导是至关重要的血管形态发生，包括动脉和静脉分化和内皮尖端和茎细胞的规格在萌芽血管生成和血管成熟的特点是壁细胞分化和招聘。Notch信号也是成人血管稳态所必需的，通过保持静止的指骨细胞重新进入细胞周期和调节内皮祖细胞的行为。本文就Notch信号通路在血管生物学中的研究进展作一综述，并重点介绍其分子机制。
Notch signaling is an evolutionarily conserved intercellular signaling pathway that plays numerous crucial roles in vascular development and physiology. Compelling evidence indicates that Notch signaling is vital for vascular morphogenesis including arterial and venous differentiation and endothelial tip and stalk cell specification during sprouting angiogenesis and also vessel maturation featured by mural cell differentiation and recruitment. Notch signaling is also required for vascular homeostasis in adults by keeping quiescent phalanx cells from re-entering cell cycle and by modulating the behavior of endothelial progenitor cells. We will summarize recent advances of Notch pathway in vascular biology with special emphasis on the underlying molecular mechanisms.
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