FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.
FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.
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DOI：
10.1016/j.gene.2007.08.020
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发表时间：
2007-12
期刊：
影响因子：
3.5
通讯作者：
Jianwei Ye;Yong Zhang;Jialin Xu;Qiang Zhang;Dahai Zhu
中科院分区：
文献类型：
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作者：
Jianwei Ye;Yong Zhang;Jialin Xu;Qiang Zhang;Dahai Zhu
F-box蛋白是SCF （Skp1-Cullin1-F-box蛋白）复合物的关键组分，发挥E3泛素连接酶活性，参与细胞周期和信号转导。F-box蛋白通过F-box结构域与Skp1相互作用，并通过其他相互作用结构域与泛素化蛋白相互作用。我们描述了一种新的肌肉特异性F-box蛋白FBXO40，其表达在肢体带状肌营养不良症（LGMD）患者的营养不良肌肉中减少。在骨骼肌发育过程中，FBXO40只能在出生后约2周的出生后期检测到。通过在C2C12细胞中过表达，FBXO40定位于细胞质中。最重要的是，FBXO40的表达可以在去神经支配的骨骼肌中上调，而不是在饥饿相关的肌肉萎缩中上调。我们所有的数据都表明FBXO40可能在出生后肌肉发生中起调节作用。
F-box proteins are key components of SCF (Skp1–Cullin1–F-box protein) complexes, which exert E3 ubiquitin ligase activity and participate in cell cycle and signal transduction. F-box proteins interact with Skp1 through the F-box domain and with proteins to be ubiquitinated through other interaction domains. We have characterized a novel muscle-specific F-box protein, FBXO40, the expression of which decreases in the dystrophic muscle of Limb-girdle muscular dystrophy (LGMD) patient. During the development of skeletal muscle, FBXO40 can only be detected at postnatal stage from about 2 weeks after birth. By overexpressing in C2C12 cells, FBXO40 localized in cytoplasm. Most importantly, the expression of FBXO40 can be upregulated in skeletal muscle from denervation- but not starvation-related muscle atrophy. All our data suggest that FBXO40 may function as a regulator involved in the postnatal myogenesis.