Anti-inflammatory activity of Rhodiola rosea - "a second-generation adaptogen"
Anti-inflammatory activity of Rhodiola rosea - "a second-generation adaptogen"
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DOI：
10.1002/ptr.2749
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发表时间：
2009-08-01
影响因子：
7.2
通讯作者：
Khanum, Farhath
中科院分区：
文献类型：
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作者：
Pooja;Bawa, A. S.;Khanum, Farhath
红景天（金根）是一种生长在高海拔地区的独特植物适应原，因其多种治疗特性而受到关注。在印度，这种植物发现于喜马拉雅山带，但尚未完全探索其有益健康的作用。本研究旨在评估红景天根酊提取物（RTE）的抗炎功效。通过大鼠模型中角叉菜胶诱导的爪水肿、甲醛诱导的关节炎和制霉菌素诱导的爪水肿来测定抗炎活性。酊提取物在250mg/kg体重的剂量下表现出对急性和亚急性炎症的抑制作用。还以剂量依赖性方式观察到对制霉菌素诱导的水肿的抑制。评估了玫瑰根酊提取物对与炎症相关的酶的体外抑制作用。这些酶包括环氧合酶-1 (COX-1)、环氧合酶-2 (COX-2) 和磷脂酶 A(2) (PLA(2))。提取物对这些酶表现出不同的抑制活性，具体取决于浓度。观察到对 Cox-2 和 PLA(2) 的有效抑制。对制霉菌素诱导的水肿和磷脂酶 A(2) 的抑制表明膜稳定可能是 RTE 抗炎作用的最可能机制。这项研究的结果可能提供玫瑰根提取物在治疗炎症方面的用途。版权所有 (C) 2009 John Wiley & Sons, Ltd.
Rhodiola rosea (golden root), a unique phytoadaptogen grown in high-altitude regions has gained attention for its various therapeutic properties. In India, this plant is found in the Himalayan belt and has not been completely explored for its beneficial health effects. The present study was undertaken to evaluate the anti-inflammatory efficacy of the tincture extract of Rhodiola rosea roots (RTE). The anti-inflammatory activity was determined through carrageenan-induced paw oedema, formaldehyde-induced arthritis and nystatin-induced paw oedema in rat model. The tincture extract exhibited inhibitory effect against acute and subacute inflammation at a dose of 250 mg/kg body weight. Inhibition of nystatin-induced oedema was also observed in a dose-dependent manner. The in vitro inhibitory effects of the tincture extract from R. rosea roots was evaluated against the enzymes relating to inflammation. The enzymes include cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Phospholipase A(2) (PLA(2)). The extract showed varying inhibitory activities against these enzymes depending on the concentrations. A potent inhibition was observed against Cox-2 and PLA(2). Inhibition of nystatin induced oedema and phospholipase A(2) suggested that membrane stabilization could be the most probable mechanism of action of RTE in anti-inflammation. The findings in this study may provide the use of R. rosea root extract in the treatment of inflammatory conditions. Copyright (C) 2009 John Wiley & Sons, Ltd.