The DNA damage response during an unperturbed S-phase
The DNA damage response during an unperturbed S-phase
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DOI：
10.1016/j.dnarep.2007.02.005
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发表时间：
2007-07-01
期刊：
影响因子：
3.8
通讯作者：
Dupre, Aude
中科院分区：
文献类型：
--
作者：
Ben-Yehoyada, Merav;Gautier, Jean;Dupre, Aude
DNA复制是一个高度保守和受控的过程。为了保持基因组的完整性，在染色体分离到子细胞之前，DNA必须忠实地复制一次。在DNA复制过程中对细胞的实验性损伤会引发一系列反应，帮助细胞应对DNA损伤和复制压力。这被称为DNA损伤反应。在未受干扰的s期，DNA损伤和异常DNA结构是正常DNA复制的结果。最近的数据表明，在面对低水平损伤时，调节急性DNA损伤反应的相同途径也在正常的s期起作用，以维持基因组的完整性。本综述将重点关注关键蛋白和信号通路的作用，这些蛋白和信号通路最初是通过在实验损伤后的DNA复制过程中维持基因组稳定性的需要而被发现的，它们在正常s期的进展调节中起着重要作用。(C) 2007 Elsevier B.V.版权所有
DNA replication is a highly conserved and controlled process. To maintain genome integrity, the DNA must be faithfully duplicated once before chromosomes are segregated to daughter cells. Experimental insults to cells during DNA replication trigger an array of responses to help cells cope with DNA damage and replication stress. This has been coined the DNA damage response. During an unperturbed S-phase, DNA lesions and aberrant DNA structures arise as a consequence of normal DNA replication. Recent data suggest that the same pathways regulating the response to acute DNA damage also operate during normal S-phase to maintain genome integrity in the face of low levels of damage. This review will focus on the role of key proteins and signaling pathways, originally identified by their requirement to maintain genome stability during DNA replication following experimental insults, in the regulation of progression through normal S-phase. (C) 2007 Elsevier B.V. All rights reserved.