Vitamin D and Parkinson's disease - A hypothesis
Vitamin D and Parkinson's disease - A hypothesis
复制标题
DOI：
10.1002/mds.21317
复制
发表时间：
2007-03-15
影响因子：
8.6
通讯作者：
Newmark, Jonathan
中科院分区：
文献类型：
--
作者：
Newmark, Harold L.;Newmark, Jonathan
帕金森病（Parkinson's disease，PD）是一种常见的老年人疾病，是一种以震颤、运动不能和姿势反射丧失为特征的运动障碍，导致不动和频繁的福尔斯。它是由大脑黑质区域中多巴胺能神经元的选择性丧失（死亡）引起的，尽管使用了当前的治疗方式，但在临床诊断之前大部分发生，并且在诊断之后持续发生。在美国的PD中，黑质中持续神经元细胞死亡的原因和机制目前尚不清楚。我们假设，根据几个方面的证据，在美国，特别是在北方州，特别是在老年人中，记录的长期维生素D摄入不足是PD发病机制的一个重要因素。这一假设意味着饮食辅助预防和治疗PD是可能的。(c)2007年，《社会运动》创刊。
Parkinson's disease (PD), a common disease of the elderly, is a movement disorder characterized by tremor, akinesia, and loss of postural reflexes, leading to immobility and frequent falls. It results from selective loss (death) of dopaminergic neurons in the substantia nigra region of the brain, largely developed prior to clinical diagnosis, and continuous after diagnosis, despite use of current therapeutic modalities. In PD in the United States the cause and mechanism of continued neuron cell death in the substantia nigra is currently unknown. We hypothesize, based upon several lines of evidence, that documented chronically inadequate vitamin D intake in the United States, particularly in the northern states and particularly in the elderly, is a significant factor in the pathogenesis of PD. This hypothesis implies that dietary aid for prevention and therapy for PD is possible. (c) 2007 Movement Disorder Society.