What are the factors driving antimicrobial resistance? Perspectives from a public event in London, England.
What are the factors driving antimicrobial resistance? Perspectives from a public event in London, England.
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DOI：
10.1186/s12879-016-1810-x
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发表时间：
2016-09-02
影响因子：
3.7
通讯作者：
Holmes AH
中科院分区：
文献类型：
--
作者：
Castro-Sánchez E;Moore LS;Husson F;Holmes AH
抗生素耐药性由多种因素驱动。解决耐药感染对人类和动物健康的威胁仍然是一项社会挑战，需要科学家和公民之间的密切合作。我们比较了目前公众对抗菌素耐药性关键因素的看法与专家表达的看法。在回顾文献后，确定了导致抗生素耐药性的主要因素。然后，这些因素被用简单的语言描述，并在一所大学组织的公众参与活动中附在投票箱上。在事件结束时对每个因素的反应进行计数。从3750名访问者那里收到了405份答复（答复率为11%）。近一半的答复（192/405，47.4%）认为人类滥用/过度使用抗生素是抗菌素耐药性的主要决定因素。动物卫生中抗生素滥用的调查占16.3%（66/405）。然而，缺乏诊断感染的快速测试获得了10/405票（2.47%），缺乏有效疫苗获得了一票（0.25%）。大多数答复将抗药性感染的出现归因于人类和动物滥用抗生素。次优剂量、诊断可用性和环境污染被认为对抗菌素耐药性的发展影响较小。专家们日益认识到耐药性的更广泛、多方面的驱动因素，但公众尚未对此产生共鸣。
Antimicrobial resistance is driven by multiple factors. Resolving the threat to human and animal health presented by drug-resistant infections remains a societal challenge that demands close collaboration between scientists and citizens. We compared current public views about key contributing factors to antimicrobial resistance with those expressed by experts. Overarching factors contributing to antimicrobial resistance were identified following a review of literature. The factors were then described in plain language and attached to ballot boxes at a public engagement event organised by a university. Responses to each factor were counted at the end of the event. Four hundred five responses were received from 3750 visitors (11 % response rate). Nearly half of responses (192/405, 47 · 4 %) considered the misuse/overuse of antibiotics in humans as the main determinant of antimicrobial resistance. The misuse of antibiotics in animal health obtained 16 · 3 % (66/405) responses. However, the lack of quick tests to diagnose infections received 10/405 votes (2 · 47 %), and the lack of effective vaccines received one vote (0 · 25 %). The majority of responses ascribed the emergence of drug-resistant infections to the misuse of antibiotics in human and animals. Suboptimal dosing, availability of diagnostics and environmental contamination were considered less influential on the development of antimicrobial resistance. The growing recognition of broader multifaceted drivers of drug resistance by experts is not yet echoed in the public mind.
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影响因子：
168.9
作者：
Holmes, Alison H.;Moore, Luke S. P.;Piddock, Laura J. V.
通讯作者：
Piddock, Laura J. V.
影响因子：
168.9
作者：
Laxminarayan, Ramanan;Matsoso, Precious;Davies, Sally
通讯作者：
Davies, Sally
影响因子：
4
作者：
Pai, Manjunath P.
通讯作者：
Pai, Manjunath P.
影响因子：
4.4
作者：
Smith RA;Quesnell M;Glick L;Hackman N;M'Ikanatha NM
通讯作者：
M'Ikanatha NM
影响因子：
5.2
作者：
McNulty, Cliodna A. M.;Boyle, Paul;Davey, Peter
通讯作者：
Davey, Peter