The structure of sensory afferent compartments in health and disease.
The structure of sensory afferent compartments in health and disease.
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DOI：
10.1111/joa.13544
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发表时间：
2022-11
影响因子：
2.4
通讯作者：
Dawes, John M.
中科院分区：
文献类型：
--
作者：
Middleton, Steven J.;Perez-Sanchez, Jimena;Dawes, John M.
关键词：
初级感觉神经元是能够对无害和有害刺激做出反应的异质细胞群。像大多数神经元一样，它们是高度分隔的，使它们能够检测、传达和传递感官信息。这些区室包括皮肤中的专门感觉末梢、有髓轴突中的朗维尔结、脊髓中的细胞索马和它们的中央终末。在这篇综述中，我们将强调这些隔间的重要性，初级传入功能，描述这些结构是如何受损后神经损伤，这是如何与神经性疼痛。像大多数神经元一样，感觉传入神经是高度区室化的。在这篇综述中，我们将讨论感觉神经元内的不同隔间的结构，它们如何与正常的感觉功能和突出的解剖学变化发生在这些隔间神经损伤和神经病理性疼痛的关系。
Primary sensory neurons are a heterogeneous population of cells able to respond to both innocuous and noxious stimuli. Like most neurons they are highly compartmentalised, allowing them to detect, convey and transfer sensory information. These compartments include specialised sensory endings in the skin, the nodes of Ranvier in myelinated axons, the cell soma and their central terminals in the spinal cord. In this review, we will highlight the importance of these compartments to primary afferent function, describe how these structures are compromised following nerve damage and how this relates to neuropathic pain. Like most neurons, sensory afferents are highly compartmentalised. In this review we will discuss the structure of distinct compartments within sensory neurons, how they relate to normal sensory function and highlight anatomical changes which occur to these compartments following nerve injury and their relationship to neuropathic pain.
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