Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients
Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients
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DOI：
10.1136/oem.2008.040857
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Hoek, G.
中科院分区：
文献类型：
--
作者：
de Hartog, J. J.;Ayres, J. G.;Hoek, G.
目的：与使用中心站点相关的暴露错误分类可能对超细颗粒物的影响大于对颗粒物（2.5 mm和10 mm（PM2.5和PM10））的影响，并可能导致对健康影响的低估。本文描述了室外和室内暴露于超细颗粒物、PM2.5和PM10与肺功能之间相关性的相对强度。在四个欧洲城市（赫尔辛基、雅典、阿姆斯特丹和伯明翰），肺功能（用力肺活量（FVC），对135例哮喘和慢性阻塞性肺疾病（COPD）患者进行了1秒用力呼气容积（FEV1）和最大呼气流量（PEF）的测定，研究期为1年。在每个城市的一个中心点和受试者的家内外测量了颗粒物数、PM2.5和PM10的日浓度。我们发现24小时平均颗粒数或颗粒质量浓度与FVC，FEV1和PEF之间没有关联。替代家庭室外或家庭室内的颗粒空气污染浓度，而不是中央站点的测量没有改变所观察到的关联。仅限于哮喘患者的分析也没有显示出association.Conclusions：肺功能和24小时平均颗粒数或颗粒质量浓度之间没有一致的协会被发现在面板的患者轻度至中度COPD或哮喘。更详细的暴露评估并没有改变观察到的相关性。缺乏相关性可能是由于药物使用的高流行率，评估几天内滞后效应的能力有限或缺乏效应。
Objectives: Misclassification of exposure related to the use of central sites may be larger for ultrafine particles than for particulate matter (2.5 mm and (10 mm (PM2.5 and PM10) and may result in underestimation of health effects. This paper describes the relative strength of the association between outdoor and indoor exposure to ultrafine particles, PM2.5 and PM10 and lung function.Methods: In four European cities (Helsinki, Athens, Amsterdam and Birmingham), lung function (forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and peak expiratory flow (PEF)) was measured three times a day for 1 week in 135 patients with asthma or chronic obstructive pulmonary disease (COPD), covering study periods of 1 year. Daily concentrations of particle number, PM2.5 and PM10 were measured at a central site in each city and both inside and outside the subjects' homes.Results: Daily average particle number concentrations ranged between 2100 and 66 100 particles/cm(3). We found no association between 24 h average particle number or particle mass concentrations and FVC, FEV1 and PEF. Substituting home outdoor or home indoor concentrations of particulate air pollution instead of the central site measurements did not change the observed associations. Analyses restricted to asthmatics also showed no associations.Conclusions: No consistent associations between lung function and 24 h average particle number or particle mass concentrations were found in panels of patients with mild to moderate COPD or asthma. More detailed exposure assessment did not change the observed associations. The lack of association could be due to the high prevalence of medication use, limited ability to assess lagged effects over several days or absence of an effect.