Feasibility of collecting tumor samples of breast cancer patients diagnosed up to 50 years ago in the Child Health and Development Studies.
Feasibility of collecting tumor samples of breast cancer patients diagnosed up to 50 years ago in the Child Health and Development Studies.
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在儿童健康与发展研究中收集 50 年前诊断出的乳腺癌患者的肿瘤样本的可行性。
DOI：
10.1017/s204017441700006x
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发表时间：
2017
影响因子：
1.7
通讯作者：
Cohn,BA
中科院分区：
文献类型：
--
作者：
Krigbaum,NY;Rubin,RA;Cirillo,PM;Terry,MB;Habel,LA;Morris,C;Cohn,BA
怀孕期间的环境暴露可能会增加母亲和女性后代患乳腺癌的风险。肿瘤组织测定可以提供有关机制的见解。本研究评估了从 1959 年至 1967 年怀孕期间参加儿童健康与发展研究的母亲 (F0) 及其在 50 多年的随访中患乳腺癌的女儿 (F1) 获取肿瘤样本和病理报告的可行性。乳腺癌病例是通过与加州癌症登记处的联系和自我报告来确定的。获得了 116 名 F0 和 95 名 F1 乳腺癌幸存者的书面同意，以获取他们的病理报告和肿瘤块。在联系的人中，62% 同意，13% 拒绝，24% 没有回应。我们获得了 57% 的组织样本和 75% 的病理报告，如果诊断 ⩽10 年，我们分别获得了 91% 和 79% 的组织样本和病理报告。获得两代人的病理报告和肿瘤组织是可行的，并将支持研究早期暴露与分子肿瘤标志物之间的关系。然而，我们发现最近的诊断增加了肿瘤组织的可及性。我们建议队列在研究入组时请求同意获取未来的肿瘤组织，并实施实时组织收集，以提高收集肿瘤样本和数据的成功率。
Environmental exposures during pregnancy may increase breast cancer risk for mothers and female offspring. Tumor tissue assays may provide insight regarding the mechanisms. This study assessed the feasibility of obtaining tumor samples and pathology reports from mothers (F0) who were enrolled in the Child Health and Development Studies during pregnancy from 1959 to 1967 and their daughters (F1) who developed breast cancer over more than 50 years of follow-up. Breast cancer cases were identified through linkage to the California Cancer Registry and self-report. Written consent was obtained from 116 F0 and 95 F1 breast cancer survivors to access their pathology reports and tumor blocks. Of those contacted, 62% consented, 13% refused and 24% did not respond. We obtained tissue samples for 57% and pathology reports for 75%, and if diagnosis was made ⩽10 years we obtained tissue samples and pathology reports for 91% and 79%, respectively. Obtaining pathology reports and tumor tissues of two generations is feasible and will support investigation of the relationship between early-life exposures and molecular tumor markers. However, we found that more recent diagnosis increased the accessibility of tumor tissue. We recommend that cohorts request consent for obtaining future tumor tissues at study enrollment and implement real-time tissue collection to enhance success of collecting tumor samples and data.