Disappearance rates of endogenous follicle-stimulating hormone in serum following surgical hypophysectomy in man.
Disappearance rates of endogenous follicle-stimulating hormone in serum following surgical hypophysectomy in man.
复制标题
男性垂体切除术后血清中内源性卵泡刺激激素的消失率。
DOI：
10.1097/00006254-197009000-00016
复制
发表时间：
1970
期刊：
影响因子：
--
通讯作者：
A. Littell
中科院分区：
文献类型：
--
作者：
S. Yen;L. Llerena;O. Pearson;A. Littell
本文测定了5例垂体全切除术后血清内源性FSH的消失率。1例同时测定血清FSH和LH。通过特异性放射免疫测定法测量激素浓度。内源性FSH从循环中消失的速度比内源性LH慢得多（约10倍）。FSH的消失率与LH的消失率一样，可分解为至少2个指数分量。初始快速分量的平均t1/2为3.9小时，随后是第二缓慢分量，平均t1/2为70.4小时。
ABSTRACT The disappearance rates of endogenous FSH in serum following complete hypophysectomy were determined in 5 patients. Simultaneous determinations of serum FSH and LH were made in one patient. The hormone concentrations were measured by specific radioimmunoassays. Endogenous FSH disappears from circulation at a much slower rate than endogenous LH (approximately 10-fold). The disappearance rates for FSH, like that of LH, could be resolved into at least 2 exponential components. The initial fast component has a mean t½ of 3.9 hr, which was followed by a second slow component with a mean t½ of 70.4 hr.