Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations.
Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations.
复制标题
对活化蛋白 C 和 Arg 506 Gln V 因子突变的抵抗在东亚人群中并不常见。
DOI：
10.1159/000203548
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发表时间：
1997
影响因子：
2.4
通讯作者：
Kiyoshi Kitano
中科院分区：
文献类型：
--
作者：
Hiroshi Kodaira;Fumihiro Ishida;Shigetaka Shimodaira;Osamu Takamiya;Kenichi Furihata;Kiyoshi Kitano
我们调查了来自东亚三个国家(日本270例，中国113例，韩国93例)的健康受试者和26例发生静脉血栓事件的日本患者的凝血因子V(FV)Arg506Gln突变的发生率。患者还使用Coatest APC抗性试剂盒检测APC的耐药性。用聚合酶链式反应和限制性内切酶酶切技术检测FV基因突变。所有受检者均为FV基因506位Arg纯合子，无APC耐药。我们的结果表明，FV突变和APC耐药在东亚静脉血栓性疾病中的作用很小。
We investigated the prevalence of the factor V (FV) Arg 506 Gln mutation in healthy subjects from three eastern Asian countries (Japan, n = 270; China, n = 113; and Korea, n = 93) and in 26 Japanese patients showing venous thromboembolic events. The patients were also examined for activated protein C (APC) resistance by using the Coatest APC resistance kit. The FV mutation was investigated by polymerase chain reaction and restricted enzyme digestion with MnlI RFLP assay of the FV gene. None of the patients showed APC resistance, while all subjects examined were homozygous for Arg at position 506 of the FV gene. Our results imply that FV mutation and APC resistance contribute little to venous thrombotic diseases in eastern Asia.