Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage.
Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage.
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DOI：
10.1002/ijc.27689
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发表时间：
2013-02-01
影响因子：
6.4
通讯作者：
Kiviat, Nancy B.
中科院分区：
文献类型：
--
作者：
Xi, Long Fu;Schiffman, Mark;Koutsky, Laura A.;He, Zhonghu;Winer, Rachel L.;Hulbert, Ayaka;Lee, Shu-Kuang;Ke, Yang;Kiviat, Nancy B.
Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who had a newly detected HPV31 infection during a 2-year follow-up with 6-month intervals. HPV31 isolates were characterized by sequencing and assigned to 1 of 3 variant lineages. Loss of the newly detected HPV31 infection was detected in 76 (47.5%) of the 160 women (32/67 with A variants, 16/27 with B variants, and 28/66 with C variants). The adjusted hazard ratio associating loss of the infection was 1.2 (95% CI, 0.7–2.1) for women with A variants and 2.1 (95% CI, 1.2–3.5) for women with B variants as compared to those with C variants. Infections with A and C variants were detected in 50 and 41 Caucasian women and in 15 and 23 African-American women, respectively. The likelihood of clearance of the infection was significantly lower in African-American women with C variants than in African-American women with A variants (P=0.05). There was no difference in the likelihood of clearance between A and C variants among Caucasian women. Our data indicated that infections with B variants were more likely to resolve than those with C variants. The difference in clearance of A versus C variants in African-Americans but not in Caucasians suggests a possibility of the race-related influence in retaining the variant-specific infection.
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影响因子：
2.7
作者：
Safaeian, Mahboobeh;van Doorslaer, Koenraad;Schiffman, Mark;Chen, Zigui;Rodriguez, Ana Cecilia;Herrero, Rolando;Hildesheim, Allan;Burk, Robert D.
通讯作者：
Burk, Robert D.
影响因子：
12.7
作者：
Raiol, Taina;Wyant, Patricia Soares;Fernandes Martins, Claudia Renata
通讯作者：
Fernandes Martins, Claudia Renata
影响因子：
8.8
作者：
Munoz, N.;Hernandez-Suarez, G.;Mendez, F.;Molano, M.;Posso, H.;Moreno, V.;Murillo, R.;Ronderos, M.;Meijer, C.;Munoz, A.
通讯作者：
Munoz, A.
影响因子：
3.8
作者：
Villa, LL;Sichero, L;Franco, EL
通讯作者：
Franco, EL
影响因子：
120.7
作者：
Schlecht, NF;Kulaga, S;Franco, EL
通讯作者：
Franco, EL