Examining the relationships between cortical maturation and white matter myelination throughout early childhood
Examining the relationships between cortical maturation and white matter myelination throughout early childhood
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DOI：
10.1016/j.neuroimage.2015.10.038
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发表时间：
2016-01-15
期刊：
影响因子：
5.7
通讯作者：
Deoni, Sean C. L.
中科院分区：
文献类型：
--
作者：
Croteau-Chonka, Elise C.;Dean, Douglas C., III;Deoni, Sean C. L.
皮质发育和白色物质髓鞘形成是婴儿和儿童神经发育的标志性过程，并且在认知和行为功能的进化中起核心作用。非侵入性磁共振成像（MRI）已被用来独立跟踪这些微观结构和形态学的变化在体内，但是很少有研究调查它们之间的关系，尽管它们在发育中的大脑的并发症。此外，由于皮质形态的测量依赖于潜在的灰-白色物质组织对比度，其本身是白色物质髓鞘形成的函数，因此不清楚皮质发育的基于对比度的测量是否准确地反映了皮质结构，或者它们是否仅表示相邻的白色物质成熟。这在幼儿中可能尤其如此，他们的大脑结构正在迅速成熟。在这里，我们第一次调查的动态关系之间的皮质和白色物质的发展，整个幼儿期，从1至6岁。我们目前的测量皮质厚度相对于皮质和相邻的髓鞘水分数（MWF）在33个双边皮质区域。66个皮质区中只有14个（21%）的显著结果表明，皮质厚度测量并不受相邻白色物质变化的影响，皮质和白色物质成熟的脑成像研究反映了不同的，但互补的神经发育过程。(C)2015年，作者。爱思唯尔公司出版
Cortical development and white matter myelination are hallmark processes of infant and child neuro-development, and play a central role in the evolution of cognitive and behavioral functioning. Non-invasive magnetic resonance imaging (MRI) has been used to independently track these microstructural and morphological changes in vivo, however few studies have investigated the relationship between them despite their concurrency in the developing brain. Further, because measures of cortical morphology rely on underlying gray-white matter tissue contrast, which itself is a function of white matter myelination, it is unclear if contrast-based measures of cortical development accurately reflect cortical architecture, or if they merely represent adjacent white matter maturation. This may be particularly true in young children, in whom brain structure is rapidly maturing. Here for the first time, we investigate the dynamic relationship between cortical and white matter development across early childhood, from 1 to 6 years. We present measurements of cortical thickness with respect to cortical and adjacent myelin water fraction (MWF) in 33 bilateral cortical regions. Significant results in only 14 of 66 (21%) cortical regions suggest that cortical thickness measures are not heavily driven by changes in adjacent white matter, and that brain imaging studies of cortical and white matter maturation reflect distinct, but complimentary, neurodevelopmental processes. (C) 2015 The Authors. Published by Elsevier Inc.