Plasticity in the maternal circuit: Effects of maternal experience on Fos-lir in hypothalamic, limbic, and cortical structures in the postpartum rat
Plasticity in the maternal circuit: Effects of maternal experience on Fos-lir in hypothalamic, limbic, and cortical structures in the postpartum rat
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DOI：
10.1037/0735-7044.110.3.567
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发表时间：
1996-06-01
影响因子：
1.9
通讯作者：
Korsmit, M
中科院分区：
文献类型：
--
作者：
Fleming, AS;Korsmit, M
为了确定产后大鼠在获得和保留母性经验期间哪些大脑部位被激活，3项研究检查了在重新接触幼崽和幼崽相关线索后大脑中显示Fos样免疫反应性（Fos-lir）的细胞数量。母性经验和缺乏经验的大鼠。产后第1天，大鼠与幼鼠进行2或4小时的互动体验，然后在4或10天后再次暴露于穿孔盒中的幼鼠或中性刺激（仅穿孔盒）。在测试阶段结束时，制备脑用于Fos-lir的免疫组织化学检测。有经验和无经验的大鼠之间表现出最一致差异的大脑部位是内侧视前区、基底外侧杏仁核、顶叶皮层和前额叶皮层。
To determine what brain sites are activated during the acquisition and retention of a maternal experience in postpartum rats, 3 studies examined the number of cells showing Fos-like immunoreactivity (Fos-lir) in brains following reexposure to pups and pup-associated cues in maternally experienced and inexperienced rats. Day 1 postpartum rats were given a 2- or 4-hr interactive experience with pups and then reexposed to pups in a perforated box, or to a neutral stimulus (perforated box only) 4 or 10 days later. At the end of the test phase, brains were prepared for immunohistochemical detection of Fos-lir. The brain sites showing the most consistent difference between experienced and inexperienced rats were the medial preoptic area, the basolateral amygdala, the parietal cortex, and the prefrontal cortex.