The complex TIE between macrophages and angiogenesis
The complex TIE between macrophages and angiogenesis
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DOI：
10.1111/ahe.12518
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发表时间：
2019-11-27
影响因子：
0.9
通讯作者：
De Spiegelaere, Ward
中科院分区：
文献类型：
--
作者：
Du Cheyne, Charis;Tay, Hanna;De Spiegelaere, Ward
巨噬细胞主要被称为吞噬免疫细胞，但它们也在不同的过程中发挥作用，如形态发生，稳态和再生。在这篇综述中，我们讨论了巨噬细胞对血管生成的影响，新的血管形成的过程中，从预先存在的血管。巨噬细胞在血管生成级联反应的每一步都起着至关重要的作用，从新血管发芽到血管丛的重塑和血管成熟。巨噬细胞形成了有希望的促血管生成和抗血管生成治疗的靶点。然而，为了靶向巨噬细胞，我们首先需要了解在血管生成级联反应的每个步骤中控制巨噬细胞功能可塑性的机制。在这里，我们回顾了最近在这个主题的见解。将特别关注表达TIE 2的巨噬细胞（TEM），这是一种高度血管生成的巨噬细胞亚型，能够通过血管生成素-TIE途径影响血管生成。
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration. In this review, we discuss the influence of macrophages on angiogenesis, the process of new blood vessel formation from the pre-existing vasculature. Macrophages play crucial roles at each step of the angiogenic cascade, starting from new blood vessel sprouting to the remodelling of the vascular plexus and vessel maturation. Macrophages form promising targets for both pro- and anti-angiogenic treatments. However, to target macrophages, we will first need to understand the mechanisms that control the functional plasticity of macrophages during each of the steps of the angiogenic cascade. Here, we review recent insights in this topic. Special attention will be given to the TIE2-expressing macrophage (TEM), which is a subtype of highly angiogenic macrophages that is able to influence angiogenesis via the angiopoietin-TIE pathway.