Hyperferritinemia is a risk factor for steatosis in chronic liver disease
Hyperferritinemia is a risk factor for steatosis in chronic liver disease
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DOI：
10.3748/wjg.15.2132
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发表时间：
2009-05-07
影响因子：
4.3
通讯作者：
Camma, Calogero
中科院分区：
文献类型：
--
作者：
Licata, Anna;Nebbia, Maria Elena;Camma, Calogero
目的：探讨慢性肝功能异常（LFTs）患者高铁蛋白水平与脂肪变性的关系。方法：对连续124例高铁素血症患者（男性> 300 ng/mL，女性> 200 ng/mL）进行评价；获得临床、生化和血清学数据、铁状态参数、HFE基因突变和体内平衡模型评估评分。脂肪变性通过超声分级为不存在或存在。只有53例患者有组织学资料。结果：男性铁蛋白平均水平为881 77 ng/mL，女性为549 82 ng/mL。诊断为慢性丙型肝炎53例（42.7%），非酒精性脂肪性肝病/非酒精性脂肪性肝炎57例（45.9%），隐源性肝损害14例（11.3%）。没有人被诊断为遗传性血色素沉着症（HH）。54例患者中有17例（32%）存在肝黄铁矿；八年级一年级，九年级二年级。总体而言，92例（74.2%）患者发生脂肪变性。通过logistic回归，铁蛋白和γ -谷氨酰转移酶是脂肪变性的独立预测因子。铁蛋白水平与血小板计数低、脂肪变性和丙型肝炎病毒感染显著相关。结论：在慢性异常LFTs无HH的非酒精患者的非肥胖队列中，高血清铁蛋白水平是脂肪变性的危险因素。(C) 2009 WIG出版社、白石登出版社。版权所有。
AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level.METHODS: One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only.RESULTS: Mean level of ferritin was 881 77 ng/mL in men and 549 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and gamma-glutamyltransferase were independent predictors of steatosis. Ferritin levels were significantly related to low platelet count, steatosis and hepatitis C virus infection.CONCLUSION: In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis. (C) 2009 The WIG Press and Baishideng. All rights reserved.