In utero origins of childhood leukaemia
In utero origins of childhood leukaemia
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DOI：
10.1016/j.earlhumdev.2004.10.004
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发表时间：
2005-01-01
影响因子：
2.5
通讯作者：
Greaves, M
中科院分区：
文献类型：
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作者：
Greaves, M
由染色体易位产生的嵌合融合基因是儿童白血病中常见的分子异常，为恶性克隆提供了独特的标志物。它们在对白血病同卵双胞胎的研究以及对存档的新生儿血斑的回顾性检查中尤其具有参考价值。这些数据表明，在儿童白血病中，大多数染色体易位发生在胎儿造血过程中的子宫内。染色体易位和白血病前期克隆在出生前出现的频率（约为100倍）远高于疾病的累积发病率或患病风险，这反映了出生后发生互补性和继发性遗传事件的必要性。后者的一个结果是疾病出生后的潜伏期非常多变，偶尔还会很长（1 - 15年）。这些自然病史为考虑儿童白血病的关键病因事件提供了一个重要的框架。（C）2004爱思唯尔爱尔兰有限公司。保留所有权利。
Chimaeric fusion genes derived by chromosome translocation are common molecular abnormalities in paediatric leukaemia and provide unique markers for the malignant clone. They have been especially informative in studies with twins concordant for leukaemia and in retrospective scrutiny of archived neonatal blood spots. These data have indicated that, in paediatric leukaemia, the majority of chromosome translocations arise in utero during foetal haemopoiesis. Chromosomal translocations and preleukaemic clones arise at a substantially higher frequency (-100x) before birth than the cumulative incidence or risk of disease, reflecting the requirement for complementary and secondary genetic events that occur postnatally. A consequence of the latter is a very variable and occasionally protracted postnatal latency of disease (1-15 years). These natural histories provide an important framework for consideration of key aetiological events in paediatric leukaemia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.