Is Rolandic epilepsy associated with abnormal findings on cranial MRI?
Is Rolandic epilepsy associated with abnormal findings on cranial MRI?
复制标题
DOI：
10.1016/j.eplepsyres.2007.06.001
复制
发表时间：
2007-07-01
影响因子：
2.2
通讯作者：
Pal, Deb K.
中科院分区：
文献类型：
--
作者：
Boxerman, Jerrold L.;Hawash, Karameh;Pal, Deb K.
Rolandic epilepsy（RE）是一种特发性癫痫综合征，因此没有损害。最近的报告表明，MRI异常不仅是常见的，但可能是特定的颞叶癫痫，并偏侧的EEG放电的一侧。然而，没有对照研究已经进行了测试MRI异常和罗兰癫痫之间的关联的假设。我们进行了一个不匹配的病例对照研究，以测试MRI异常和罗兰癫痫之间的关联的假设，使用25个典型的RE病例和25名儿童偏头痛。两名独立检查员对MRI异常进行了评级。检查者对研究假设以及病例和对照检查的身份不知情。52%的RE检查包含至少一种异常：小脑/海马异常（1例），非局限性先天性畸形（7例），皮质下。脑实质高信号2例，脑室周围高信号1例，血管周围间隙扩大6例。病例组和对照组的异常数量或类型无差异。脑电图棘波发出的半球没有异常类型。调整潜在的人口统计学和技术因素后，MRI异常与RE之间相关性的比值比为0.87，95%CI：0.18-4.33。我们得出结论，常规颅骨检查。MRI异常在RE中很常见，但并不比对照组更常见，并且不是RE的特异性。(c)2007 Elsevier B. V.保留所有权利。
Rolandic epilepsy (RE) is designated an idiopathic epilepsy syndrome, and hence no lesional. abnormalities are expected on MRI exam. Recent reports suggest that MRI abnormalities are not only common, but may be specific for temporal lobe epilepsy, and lateralized to the side of EEG discharges. However, no controlled study has been performed to test the hypothesis of association between MRI abnormalities and Rolandic epilepsy. We performed an unmatched case-control study to test the hypothesis of association between MRI abnormalities and Rolandic epilepsy, using 25 typical RE cases and 25 children with migraine. Two independent examiners rated the MRls for abnormalities. Examiners were blinded to the study hypothesis and identity of case and control exams. Fifty-two percent of RE exams contained at least one abnormality: peri/hippocampal abnormality (one case), non-localized congenital malformation (seven cases), subcortical. parenchymal, hyperintensities (two cases), periventricutar parenchymal hyperintensities (one case), dilated perivascular spaces (six cases). There was no difference between the number or type of abnormalities in cases and controls. No type of abnormality lateralized to the hemisphere from which the EEG spikes emanated. The odds ratio of association between MRI abnormalities and RE was 0.87, 95% CI: 0.18-4.33 after adjusting for potential demographic and technical factors. We conclude that routine cranial. MRI abnormalities are common in RE, but no more common than in controls, and not specific for RE.(c) 2007 Elsevier B.V. All rights reserved.