Target volume shape variation during hypo-fractionated preoperative irradiation of rectal cancer patients
Target volume shape variation during hypo-fractionated preoperative irradiation of rectal cancer patients
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DOI：
10.1016/j.radonc.2009.04.022
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发表时间：
2009-08-01
影响因子：
5.7
通讯作者：
Marijnen, Corrie
中科院分区：
文献类型：
--
作者：
Nijkamp, Jasper;de Jong, Rianne;Marijnen, Corrie
目的：为了量化直肠癌患者术前5 x 5戈伊放疗治疗的日常目标体积形状的变化。材料和方法：对于27例患者，采集俯卧位平面CT（pCT）和5个每日治疗前锥束CT（CBCT）扫描。所有扫描均描绘了CTV的子区域（MesoRect，肛门直至直肠系膜筋膜的头端）。通过pCT和CBCT描绘之间的距离量化MesoRect变形，并将其存储在表面图中。最后，评价膀胱和直肠充盈对MesoRect变形的影响。结果：在MesoRect的不同区域，存在较大的系统性和随机性变形，变形范围为1-7 mm（1 SD），最大变形位于MesoRect的前上侧。对于女性的错误高达3毫米大于男性。小相关性，r（2）
Purpose: To quantify the day-to-day target volume shape variation in rectal-cancer patients treated with preoperative 5 x 5 Gy radiotherapy.Materials and methods: For 27 patients a prone position plan-CT (pCT) and five daily pre-treatment cone-beam-CT (CBCT) scans were acquired. A sub-region of the CTV (MesoRect, anus up to the cranial end of the mesorectal-fascia) was delineated on all scans. The MesoRect deformation was quantified by the distance between pCT- and CBCT-delineations and was stored in surface-maps. Finally, the influence of bladder and rectum filling on MesoRect deformation was evaluated. Data were analyzed for male and female patients separately.Results: A large range of systematic and random deformations, 1-7 mm (1SD), on different areas of the MesoRect were found. The maximum deformations were located at the upper-anterior-side of the MesoRect. For females the errors were up to 3 mm larger than for males. Small correlations, r(2)