Platelets mediate cytotoxic T lymphocyte-induced liver damage
Platelets mediate cytotoxic T lymphocyte-induced liver damage
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DOI：
10.1038/nm1317
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发表时间：
2005-11-01
期刊：
影响因子：
82.9
通讯作者：
Guidotti, LG
中科院分区：
文献类型：
--
作者：
Iannacone, M;Sitia, G;Guidotti, LG
我们发现，血小板耗竭减少了急性病毒性肝炎小鼠模型中病毒特异性细胞毒性T淋巴细胞（CTL）的肝内蓄积和器官损伤。在血小板耗竭的小鼠中输注正常但未激活阻断的血小板恢复了CTL的积累和疾病的严重程度。相反，抗凝治疗，防止肝内纤维蛋白沉积，而不减少血小板计数并没有避免肝损伤。因此，活化的血小板有助于CTL介导的肝脏免疫病理学独立的促凝血功能。
We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes ( CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.